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Bethyl Laboratories
MBD3 Polyclonal Antibody
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FIGURE: 1 / 3
MBD3 Antibody (A302-529A) in IHC (P)
Detection of human MBD3 by immunohistochemistry. Samples: FFPE serial sections of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-MBD3 (Product # A302-529A) (Lot 1, left image) and (Product # A302-529A) (Lot 2, right image) used at a dilution of 1:1,000 (1 µg/mL). Detection: DAB. Counterstain: hematoxylin (blue).
Product Details
A302-529A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 265 and 291 of human methyl-CpG binding domain protein 3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
Regulator of genomic integrity and cellular response to DNA damage acting through ATR-mediated checkpoint signaling. Necessary for centrosome duplication. It functions as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, two molecules involved in centriole formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CpG binding domain 3; Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3; unnamed protein product
Gene Aliases: MBD3
UniProt ID: (Human) O95983
Entrez Gene ID: (Human) 53615
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
ventricular cardiac muscle tissue development
chromatin remodeling
methylation-dependent chromatin silencing
tissue development
response to nutrient levels
response to estradiol
regulation of gene expression, epigenetic
regulation of cell fate specification
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
embryonic organ development
response to bisphenol A
regulation of stem cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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