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Thermo Scientific Chemicals
Di-tert-butyl N,N-diethylphosphoramidite, 94%
CAS: 117924-33-1 | C12H28NO2P | 249.335 g/mol
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Chemical Identifiers
CAS117924-33-1
IUPAC Name[bis(tert-butoxy)phosphanyl]diethylamine
Molecular FormulaC12H28NO2P
InChI KeyKUKSUQKELVOKBH-UHFFFAOYSA-N
SMILESCCN(CC)P(OC(C)(C)C)OC(C)(C)C
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Specifications
Specification Sheet
Specification SheetAssay (GC)≥92.0%
CommentMay form small amount of sediment/precipitate upon storage.
Identification (FTIR)Conforms
Refractive Index1.4310-1.4380 @ 20?C
FormLiquid
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A useful reagent for the efficient phosphorylative conversion of alcohols into their corresponding dibenzylphosphorotriesters. It is applied as a phosphitylating agent in water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, a2a-selective adenosine receptor antagonists.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
A useful reagent for the efficient phosphorylative conversion of alcohols into their corresponding dibenzylphosphorotriesters. It is applied as a phosphitylating agent in water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, a2a-selective adenosine receptor antagonists.
Solubility
Hydrolyzes in water. Soluble in chloroform and methanol.
Notes
Moisture sensitive. Store away from water/moisture, heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Keep it refrigerated. Keep ignition sources away.
A useful reagent for the efficient phosphorylative conversion of alcohols into their corresponding dibenzylphosphorotriesters. It is applied as a phosphitylating agent in water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, a2a-selective adenosine receptor antagonists.
Solubility
Hydrolyzes in water. Soluble in chloroform and methanol.
Notes
Moisture sensitive. Store away from water/moisture, heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Keep it refrigerated. Keep ignition sources away.
RUO – Research Use Only
General References:
- Perich. J. W, et al. Di-tert-butyl N,N-diethylphosphoramidite. A new phosphitylating agent for the efficient phosphorylation of alcohols.Synthesis.,1988,2142-144.
- Roland Sauer, et al. Water-Soluble Phosphate Prodrugs of 1-Propargyl-8-styrylxanthine Derivatives, A2A-Selective Adenosine Receptor Antagonists.J. Med. Chem.,2000,43(3), 440-448.