Cefoperazone sodium salt

Name: Cefoperazone sodium salt
SKU: J65185.03

Cefoperazone sodium salt, CAS # 62893-20-3, is the sodium salt form of cefoperazone. It is a semi-synthetic, broad-spectrum, and third-generation cephalosporin compound with antibiotic and bactericidal activities. | CAS: 62893-20-3 | C25H29N9NaO8S2 | 670.672 g/mol

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Catalog number J65185.03

also known as J65185-03

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Chemical Identifiers

CAS62893-20-3

IUPAC Namesodium (6R,7R)-7-[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetamido]-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Molecular FormulaC25H26N9NaO8S2

InChI KeyNCFTXMQPRQZFMZ-WERGMSTESA-M

SMILES[Na+].CCN1CCN(C(=O)N[C@@H](C(=O)N[C@H]2[C@H]3SCC(CSC4=NN=NN4C)=C(N3C2=O)C([O-])=O)C2=CC=C(O)C=C2)C(=O)C1=O

Specifications

Specification Sheet

Assay (unspecified)Potency: 870 to 1015 µg/mg (anhydrous basis)

CommentCrystallinity: Conforms to standard

Water Content (Karl Fischer Titration)≤ 5.0%

pH4.5 to 6.5 (0.1% solution in room temperature)

Appearance (Color)White to pale cream

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Suitable for battery materials development.

General Description

• Cefoperazone sodium salt is a semi-synthetic, broad-spectrum, third-generation cephalosporin compound with antibiotic and bactericidal activities
• This compound can inhibit bacterial cell wall synthesis by inactivating penicillin-binding proteins and consequently interfering with the final transpeptidation step required for cross-linking peptidoglycan units, an important component of bacterial cell walls. This leads to a reduction in cell wall stability, causing cell lysis

Application

• Cefoperazone sodium salt exhibits activity against β-lactamase resistant microorganisms
• This compound is also used for studying the expression, binding, and inhibition of penicillin-binding proteins
• Cefoperazone is active in vitro against most gram-positive and gram-negative bacteria, including β-lactamase strains
• This compound has the ability to inhibit ∝-antitrypsin

RUO – Research Use Only

General References:

Neu, H. The in vitro activity, human pharmacology, and clinical effectiveness of new β-lactam antibiotics. Annual Reviews of Pharmacology and Toxicology. 1982, 22, 599-642.
Shahzad, M.; Abbas, A.; Rehman, R.; Mahmud, T.; Shamim, S. Comparative Analysis of Cefotaxime Sodium and Cefoperazone Sodium Drugs Activity and their Phytochemical Combinations Against Bacteria. Asian J. Chem. 2015, 27 (5), 1704-1706.
Hajime, T.; Iwasaki, M.; Ogihara, H. Development of a Novel Chromogenic Medium for Improved Campylobacter Detection from Poultry Samples. J. Food Prot. 2015, 78 (9), 1750-1755.