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Thermo Scientific Chemicals
(-)-Cotinine, 98%
CAS: 486-56-6 | C10H12N2O | 176.219 g/mol
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Catalog number L11873.MD
also known as L11873-MD
Price (JPY)
-
Quantity:
250 mg
Chemical Identifiers
CAS486-56-6
IUPAC Name1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one
Molecular FormulaC10H12N2O
InChI KeyUIKROCXWUNQSPJ-UHFFFAOYNA-N
SMILESCN1C(CCC1=O)C1=CC=CN=C1
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Specifications
Specification Sheet
Specification SheetAppearance (Color)White to cream to yellow to pale brown
FormFused solid : Clear liquid as melt
Optical Rotation-19° to -22° (c=1, ethanol)
Assay (GC)≥97.5%
(-)-Cotinine is used to activate a subpopulation of α3/ α6β2 nAChRs in monkey striatum. It binds nicotinic- and muscarinic-type acetylcholine receptors with minimal receptor desensitization and demonstrates antipsychotic drug-like properties in behavioral models, neuroprotective properties in neurodegenerative disease models, and enhances attention in a delayed matching-to-sample task.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Solubility
Not miscible or difficult to mix in water. Soluble in dimethyl sulfoxide (100 mM), ethanol (50 mg/ml, yielding a clear, faint yellow to yellow solution), methanol and chloroform.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature is 2 - 8°C.
Not miscible or difficult to mix in water. Soluble in dimethyl sulfoxide (100 mM), ethanol (50 mg/ml, yielding a clear, faint yellow to yellow solution), methanol and chloroform.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature is 2 - 8°C.
RUO – Research Use Only
General References:
- Neal L Benowitz MD.; Peyton Jacob III PhD. Metabolism of nicotine to cotinine studied by a dual stable isotope method. Clinical Pharmacology & Therapeutics. 1994, 56 (5), 483-493.
- N J Haley.; C M Axelrad.; K A Tilton. Validation of self-reported smoking behavior: biochemical analyses of cotinine and thiocyanate. American Journal of Public Health. 1983, 73 (10), 1204-1207.
- Nicotine metabolite: J. Chromat., 231, 53 (1982).