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Invitrogen
p21 Monoclonal Antibody (WA-1)
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Product Details
MA1-33926
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
WA-1
Immunogen
Human p21 protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
15mM sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Protein p21 is a tumor suppressor protein which is an inhibitor of Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. P21 is important in the response of cells to genotoxic stress and a major transcriptional target of p53 protein. The occurrence of p21 in the nucleus executes binding and inhibition activity of cyclin dependent kinases Cdk1 and Cdk2, and blocks the transition from G1 phase into S phase or from G2 phase into mitosis after DNA damage, which enables the repair of damaged DNA. In the cytoplasm, p21 protein has an anti-apoptotic effect. P21 is able to bind to and inhibit caspase 3, as well as the apoptotic kinases ASK1 and JNK. P21 exhibits a dual function in carcinogenesis, and acts as a tumor suppressor, prevents apoptosis, and acts as an oncogene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Activating Fragment 1; alternate gene name=WAF1; CDK-interacting protein 1; CDK-interaction protein 1; CDKN1A; CDNK1A; Cip1); cyclin kinase inhibitor; Cyclin-dependent kinase inhibitor 1; Cyclin-dependent kinase inhibitor 1A (p21; cyclin-dependent kinase inhibitor 1A (p21, Cip1); DNA synthesis inhibitor; MDA-6; melanoma differentiation associated protein 6; Melanoma differentiation-associated protein 6; OTTHUMP00000016298; p21; p21Cip1/Waf1; putative DNA synthesis inhibitor; SLC12A9; unnamed protein product; Wild type p53 activated fragment 1 (WAF1); wild type p53 activated fragment-1; wild-type p53-activated fragment 1
Gene Aliases: CAP20; CDKN1; CDKN1A; CIP1; MDA-6; MDA6; P21; p21CIP1; PIC1; SDI1; WAF1
UniProt ID: (Human) P38936
Entrez Gene ID: (Human) 1026
protein kinase inhibitor activity
cyclin-dependent protein serine/threonine kinase inhibitor activity
protein binding
zinc ion binding
protein kinase binding
cyclin binding
ubiquitin protein ligase binding
macromolecular complex binding
metal ion binding
protein serine/threonine kinase binding
protein sequestering activity
molecular function activator activity
molecular function inhibitor activity
G1/S transition of mitotic cell cycle
in utero embryonic development
protein import into nucleus
cellular response to DNA damage stimulus
mitotic G2 DNA damage checkpoint
Ras protein signal transduction
regulation of mitotic cell cycle
heart development
positive regulation of cell proliferation
negative regulation of cell proliferation
epidermis development
response to UV
regulation of G2/M transition of mitotic cell cycle
negative regulation of macromolecule biosynthetic process
negative regulation of gene expression
keratinocyte differentiation
negative regulation of cell growth
DNA damage response, signal transduction by p53 class mediator
positive regulation of B cell proliferation
mitotic G1 DNA damage checkpoint
cellular response to amino acid starvation
wound healing
tissue regeneration
signal transduction in response to DNA damage
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of programmed cell death
keratinocyte proliferation
positive regulation of DNA replication
positive regulation of protein kinase activity
negative regulation of growth
fibroblast proliferation
positive regulation of fibroblast proliferation
nuclear import
regulation of cell cycle
cellular response to cell-matrix adhesion
cellular response to ionizing radiation
cellular response to gamma radiation
cellular response to UV-B
signal transduction by p53 class mediator
cellular senescence
replicative senescence
stress-induced premature senescence
oncogene-induced cell senescence
intrinsic apoptotic signaling pathway
regulation of cell cycle G1/S phase transition
negative regulation of cyclin-dependent protein kinase activity
negative regulation of vascular smooth muscle cell proliferation
negative regulation of cardiac muscle tissue regeneration
regulation of G1/S transition of mitotic cell cycle
negative regulation of G1/S transition of mitotic cell cycle
regulation of DNA biosynthetic process
negative regulation of DNA biosynthetic process
positive regulation of reactive oxygen species metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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