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Invitrogen

RPS3 Recombinant Rabbit Monoclonal Antibody (3D5)

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Product Details

MA5-24847

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

3D5

Immunogen

Recombinant RPS3.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2717285

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

WD repeat domain 5 (WDR5) is a member of the WD repeat protein family, which is involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WDR5, also known as BIG-3, is expressed in the developing growth plate, accelerates chondrocyte and osteoblast differentiation in vitro, and regulates osteoblast differentiation during embryonic bone development. WDR5 interacts with the pluripotency factor Oct4/POU5F1 and is required for the efficient formation of induced pluripotent stem (iPS) cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 40S ribosomal protein S3; FLJ26283; FLJ27450; IMR-90 ribosomal protein S3; MGC87870; OTTHUMP00000229804; OTTHUMP00000229805; OTTHUMP00000229874; OTTHUMP00000229877; OTTHUMP00000229878; OTTHUMP00000229879; OTTHUMP00000229880; OTTHUMP00000229882; OTTHUMP00000229883; OTTHUMP00000229886; Small ribosomal subunit protein uS3; unnamed protein product

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Gene Aliases: D7Ertd795e; OK/SW-cl.26; RPS3; Rs_3; S3; uS3

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UniProt ID: (Human) P23396, (Mouse) P62908, (Rat) P17073

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Entrez Gene ID: (Human) 6188, (Mouse) 27050, (Rat) 140654

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding DNA binding damaged DNA binding RNA binding mRNA binding structural constituent of ribosome DNA-(apurinic or apyrimidinic site) lyase activity endodeoxyribonuclease activity protein binding microtubule binding tubulin binding lyase activity DNA N-glycosylase activity enzyme binding kinase binding protein kinase binding Hsp70 protein binding oxidized purine DNA binding oxidized pyrimidine DNA binding ubiquitin-like protein conjugating enzyme binding macromolecular complex binding protein kinase A binding iron-sulfur cluster binding Hsp90 protein binding small ribosomal subunit rRNA binding supercoiled DNA binding class I DNA-(apurinic or apyrimidinic site) endonuclease activity DNA-binding transcription factor binding nucleic acid binding oxidized purine nucleobase lesion DNA N-glycosylase activity poly(A) RNA binding NF-kappaB binding ribosomal protein
Process(es)
cytoplasmic translation DNA repair base-excision repair translation translational initiation regulation of translation apoptotic process cellular response to DNA damage stimulus chromosome segregation positive regulation of gene expression negative regulation of translation positive regulation of microtubule polymerization positive regulation of protein complex assembly negative regulation of protein ubiquitination positive regulation of endodeoxyribonuclease activity positive regulation of interleukin-2 production cellular response to reactive oxygen species positive regulation of activated T cell proliferation regulation of apoptotic process negative regulation of DNA repair positive regulation of DNA repair positive regulation of T cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity spindle assembly cell division response to TNF agonist cellular response to hydrogen peroxide cellular response to tumor necrosis factor positive regulation of NIK/NF-kappaB signaling positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of base-excision repair positive regulation of apoptotic signaling pathway DNA metabolic process transcription, DNA-templated regulation of transcription, DNA-templated cell cycle mitotic nuclear division nucleic acid phosphodiester bond hydrolysis positive regulation of DNA N-glycosylase activity DNA catabolic process, endonucleolytic
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