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Invitrogen
Calsequestrin Recombinant Rabbit Monoclonal Antibody (5P6U2)
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Product Details
MA5-37936
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
5P6U2
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 100-200 of human Calsequestrin 1 (NP_0012223)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.3 mg/mL
Amount
130 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: Rat heart
Immunogen sequence: EDKGVGFGLV DSEKDAAVAK KLGLTEVDSM YVFKGDEVIE YDGEFSADTI VEFLLDVLED PVELIEGERE LQAFENIEDE IKLIGYFKSK DSEHYKAFED A
Target Information
The sarcoplasmic reticulum (SR) is, in part, responsible for maintaining the level of intracellular calcium in cardiac and skeletal muscle by storing and releasing calcium. Several intralumenal SR calcium binding proteins have been identified, the most prominent of these is calsequestrin. Calsequstrin is a calcium binding protein known to sequester calcium accumulated in the sarcoplasmic reticulum of muscle cells during relaxation and is found discretely localized to the junctional and corbular (terminal cisternae) SR. Calsequestrin functions to localize calcium near the junctional face of the terminal cisternae from which calcium can be released into the cytosol via the ryanodine receptor. This protein is highly acidic and has a large capacity and moderate to low affinity for calcium.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Aspartactin; Calmitine; Calsequestrin, skeletal muscle isoform; Calsequestrin-1; Laminin-binding protein
Gene Aliases: Casq1; CSQ; CSQ-1; CSQ1; sCSQ
UniProt ID: (Rat) P19633, (Mouse) O09165
Entrez Gene ID: (Rat) 686019, (Mouse) 12372
endoplasmic reticulum organization
skeletal muscle tissue development
response to heat
response to organic substance
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
response to muscle inactivity
response to denervation involved in regulation of muscle adaptation
sarcomere organization
protein polymerization
regulation of sequestering of calcium ion
regulation of muscle contraction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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