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Invitrogen

STAT5 alpha Recombinant Rabbit Monoclonal Antibody (SC66-09)

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STAT5 alpha Recombinant Rabbit Monoclonal Antibody (SC66-09)

Product Details

MA5-41158

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,1000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

SC66-09

Immunogen

Synthetic peptide within C-terminal human STAT5a.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2898912

Target Information

STAT5 alpha is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5 alpha is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of STAT5 alpha in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of STAT5 alpha is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this protein in cells. STAT5 alpha, along with STAT5 beta, were identified in mouse. The amino acid sequences of STAT5 alpha and STAT5 beta show 96% sequence similarity, and both proteins are co expressed in most tissues in virgin and lactating mice. However, differential accumulation of STAT5 alpha and STAT5 beta mRNA has been reported for both muscle and mammary tissue. STAT5 alpha is critically involved in a variety of physiological functions, including reproduction, lactation, immune function and somatic growth.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: epididymis secretory sperm binding protein; lacks exon 18; mammary gland factor; mammary gland factor STAT5A; signal transducer and activator of transcription 5; STAT; STAT5B; transcription factor; unnamed protein product

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Gene Aliases: MGF; STAT5

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UniProt ID: (Human) P42229, (Rat) Q62771, (Mouse) P42230

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Entrez Gene ID: (Human) 6776, (Rat) 24918, (Mouse) 20850

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding phosphate ion binding sequence-specific DNA binding DNA-binding transcription factor binding promoter-specific chromatin binding double-stranded DNA binding
Process(es)
luteinization natural killer cell differentiation positive regulation of endothelial cell proliferation regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter defense response signal transduction JAK-STAT cascade female pregnancy lactation positive regulation of cell proliferation gene expression peptidyl-tyrosine phosphorylation regulation of steroid metabolic process cytokine-mediated signaling pathway taurine metabolic process lipid storage regulation of cell adhesion eosinophil differentiation regulation of epithelial cell differentiation mammary gland development response to nutrient levels positive regulation of interleukin-2 production positive regulation of natural killer cell differentiation negative regulation of mast cell apoptotic process T cell differentiation in thymus interleukin-15-mediated signaling pathway interleukin-4-mediated signaling pathway reelin-mediated signaling pathway interleukin-5-mediated signaling pathway interleukin-2-mediated signaling pathway interleukin-7-mediated signaling pathway interleukin-9-mediated signaling pathway interleukin-3-mediated signaling pathway thrombopoietin-mediated signaling pathway regulation of multicellular organism growth positive regulation of multicellular organism growth positive regulation of activated T cell proliferation regulation of cell proliferation T cell homeostasis negative regulation of apoptotic process response to peptide hormone positive regulation of blood vessel endothelial cell migration response to ethanol positive regulation of B cell differentiation positive regulation of gamma-delta T cell differentiation positive regulation of lymphocyte differentiation negative regulation of erythrocyte differentiation positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of natural killer cell mediated cytotoxicity development of secondary female sexual characteristics development of secondary male sexual characteristics Peyer's patch development gland development positive regulation of inflammatory response mammary gland involution positive regulation of mast cell differentiation JAK-STAT cascade involved in growth hormone signaling pathway prostate gland epithelium morphogenesis epithelial cell differentiation involved in prostate gland development mammary gland epithelium development positive regulation of mast cell proliferation cellular response to cytokine stimulus cellular response to granulocyte macrophage colony-stimulating factor stimulus negative regulation of T-helper 17 cell lineage commitment regulation of hemopoiesis
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