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Invitrogen
BAP31 Recombinant Rabbit Monoclonal Antibody (12G12)
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FIGURE: 1 / 4
BAP31 Antibody (MA5-50011) in ICC/IF
Immunocytochemistry analysis of A549 cell with BAP31 monoclonal antibody (Product # MA5-50011) at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 526-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
Product Details
MA5-50011
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
12G12
Immunogen
A synthesized peptide derived from human BCAP31
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.2 mg/mL
Amount
120 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
BAP31 (B-Cell Receptor Associated Protein, 31-kDa) is a multiple membrane spanning protein of the endoplasmic reticulum. It has been shown to form both homo- and hetero-oligomers with the closely related BAP29, and is a potential apoptotic regulator as a predicted BCL-2/BCL-XL-associated protein. In the C-terminal domain of BAP31, there are two identical recognition sites for initiator Caspases 1 and 8 of the programmed death cascade. It is hypothesized that BAP31 plays a role in the transport of selected proteins to the Golgi apparatus. BAP31 has also been shown to control expression of CFTR (cystic fibrosis transmembrane conductance regulator). It is believed that interference with the expression or function of BAP31 in epithelial cells may be a way to circumvent the chloride channel defect in cystic fibrosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 6C6 antigen; 6C6-AG tumor-associated antigen; B-cell receptor-associated protein 31; BCR-associated protein 31; BCR-associated protein Bap31; CDM protein; OTTHUMP00000025978; p28; p28 Bap31; Protein CDM; unnamed protein product
Gene Aliases: 6C6-AG; BAP31; BCAP31; CDM; DDCH; DELXQ28; DXS1357E; MICRODELXq28
UniProt ID: (Human) P51572
Entrez Gene ID: (Human) 10134
protein targeting to mitochondrion
intracellular protein transport
ER to Golgi vesicle-mediated transport
apoptotic process
spermatogenesis
protein transport
vesicle-mediated transport
response to endoplasmic reticulum stress
protein localization to endoplasmic reticulum exit site
positive regulation of retrograde protein transport, ER to cytosol
positive regulation of ERAD pathway
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of intrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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