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Invitrogen
MBTPS1 Monoclonal Antibody (2F10E12)
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FIGURE: 1 / 1
MBTPS1 Antibody (MA5-50278) in Flow
Flow cytometry analysis overlay peak curve showing Hela cells stained with MBTPS1 monoclonal antibody (Product # MA5-50278) (red line) at 1:100. The cells were incubated in 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1 µg/1*106cells) for 1h at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/100 dilution for 30 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1 µg/1*106cells) used under the same conditions. Acquisition of >10,000 event... View More
Product Details
MA5-50278
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2F10E12
Immunogen
Recombinant Human Membrane-bound transcription factor site-1 protease protein (187-400aa)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.25 mg/mL
Amount
125 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% Proclin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Endopeptidase S1P; KIAA0091; Membrane-bound transcription factor site-1 protease; proprotein convertase subtilisin/kexin type 8; site-1 protease; SKI-1; subtilisin/kexin isozyme-1; Subtilisin/kexin-isozyme 1; unnamed protein product
Gene Aliases: KIAA0091; MBTPS1; PCSK8; S1P; SEDKF; SKI-1; SKI1
UniProt ID: (Human) Q14703
Entrez Gene ID: (Human) 8720
proteolysis
protein import into nucleus
NLS-bearing protein import into nucleus
lipid metabolic process
lysosome organization
mitotic G2 DNA damage checkpoint
steroid metabolic process
cholesterol metabolic process
protein processing
endoplasmic reticulum unfolded protein response
membrane protein intracellular domain proteolysis
response to endoplasmic reticulum stress
ATF6-mediated unfolded protein response
regulation of cholesterol biosynthetic process
positive regulation of cholesterol biosynthetic process
protein maturation
regulation of vesicle-mediated transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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