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Invitrogen
PCSK9 Monoclonal Antibody (C5)
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FIGURE: 1 / 5
PCSK9 Antibody (MA5-50965) in IHC (P)
Immunohistochemistry (Paraffin) analysis of PCSK9 in Rat Cerebrum Tissue. Samples were incubated in PCSK9 monoclonal antibody (Product # MA5-50965) using a dilution of 10 µg/mL followed by HRP-Linked Caprine Anti-Mouse IgG at a dilution of 2 µg/mL and DAB staining.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-50965
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
C5
Immunogen
Recombinant Rat PCSK9 protein, Trp164-Phe428 (Accession #P59996)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
200 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% Proclin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
PCSK9 is a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. The protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hypercholesterolemia; neural apoptosis-regulated convertase 1; OTTHUMP00000009833; proprotein convertase 9; proprotein convertase PC9; subtilisin/kexin-like protease PC9
Gene Aliases: NARC-1; Narc1; PC9
UniProt ID: (Rat) P59996
Entrez Gene ID: (Rat) 298296
endopeptidase activity
serine-type endopeptidase activity
serine-type peptidase activity
sodium channel inhibitor activity
low-density lipoprotein particle binding
receptor inhibitor activity
apolipoprotein binding
very-low-density lipoprotein particle binding
apolipoprotein receptor binding
low-density lipoprotein particle receptor binding
very-low-density lipoprotein particle receptor binding
transporter inhibitor activity
kidney development
liver development
negative regulation of receptor recycling
negative regulation of receptor internalization
positive regulation of receptor internalization
proteolysis
triglyceride metabolic process
phospholipid metabolic process
lysosomal transport
cholesterol metabolic process
cellular response to starvation
negative regulation of low-density lipoprotein particle clearance
protein processing
protein autoprocessing
neurogenesis
neuron differentiation
low-density lipoprotein receptor particle metabolic process
low-density lipoprotein particle receptor catabolic process
regulation of low-density lipoprotein particle receptor catabolic process
positive regulation of low-density lipoprotein particle receptor catabolic process
cellular response to insulin stimulus
lipoprotein metabolic process
cholesterol homeostasis
regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
negative regulation of sodium ion import across plasma membrane
negative regulation of receptor-mediated endocytosis involved in cholesterol transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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