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Invitrogen
RHD Monoclonal Antibody (C1)
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FIGURE: 1 / 2
RHD Antibody (MA5-51185) in IHC (P)
Immunohistochemistry (Paraffin) analysis of RHD in human kidney tissue using RHD Monoclonal Antibody (C1) (Product # MA5-51185) (20 µg/mL) and using PBS intead of the primary antibody as a control. The sample was then stained with HRP-Goat anti-Mouse IgG polyclonal secondary antibody (2 µg/mL). DAB staining.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-51185
Product Specifications
Species Reactivity
Human,
Pig
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
C1
Immunogen
Recombinant Human RHD protein, Ser2-Gly87 (Accession #Q02161)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
200 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% Proclin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The Rhesus (Rh) blood group system represents one of the most complex and important systems in humans. Two highly homologous genes RHD and RHCE (collectively referred to as RH30 or RHCED) encode the antigens of the Rh blood group system (1-4). These tightly linked genes map to human chromosomal position 1p34.1-1p36. The RHD gene, which is commonly deleted from a large segment of the population, encodes the most potent blood group immunogen, the D antigen (2,5). Rh incompatibility between maternal and fetal blood types results in hemolytic disease of the newborn (HDN), which often results in fetal death (1,2,6). The RHCE gene exists in four allelic forms, and each allele determines the expression of two antigens in Ce, ce, cE, or CE combinations (2,4,5). The RHCED antigens exist as integral membrane proteins with contain 12-transmembrane helices, and maintain erythrocyte membrane integrity. The presentation of the Rh antigenic activity requires the formation of a complex between the RHCED antigens and RHAG (RH50).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: blood group antigen D; blood group protein RHD; D antigen (DCS); Del(L18P) protein; mutation in the fifth exon with base deletions and insertion of T and C bases; Rh blood group antigen Evans; Rh blood group C antigen; Rh blood group CcEe antigen; Rh blood group D antigen weak D type 160; Rh blood group system D-antigen; Rh blood group, D anitgen; RH polypeptide 2; Rh polypeptide II; Rh(D) Blood-Group antigen; RHD; RhD antigen; RhD blood group antigen; RhD glycoprotein; RhD polypeptide; RhD protein; RHDVI type IV variant; Rhesus blood group antigen D; rhesus D antigen; Rhesus D blood group protein; Rhesus system D polypeptide; Rhesus system D polypeptide; RH polypeptide 2; blood group Rh(D) polypeptide; D antigen (DCS); Rh blood group antigen Evans; rhesus D antigen; unnamed protein product; weak D; weak RHD antigen
Gene Aliases: CD240D; DIIIc; HDFNRH; RH; RH30; Rh4; RHCED; RhDCw; RHDel; RHDVA(TT); RhII; RhK562-II; RhPI; RHPII; RHXIII; SLC42A5
UniProt ID: (Human) Q02161
Entrez Gene ID: (Human) 6007
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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