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Invitrogen

PKC mu Recombinant Rabbit Monoclonal Antibody (23GB4590)

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PKC mu Recombinant Rabbit Monoclonal Antibody (23GB4590)

Product Details

MA5-52710

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunocytochemistry (ICC/IF)

1:1,000
-

Flow Cytometry (Flow)

1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

23GB4590

Immunogen

A synthesized peptide derived from human PKC mu (200-266AA).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3249187

Target Information

The PKC family of serine/threonine kinases, including PRKCN (PKD3), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. PKC mu activation is dependent on the phosphorylation of two activation loop sites, Ser744 and Ser748, via a PKC-dependent signaling pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZP586E0820; nPKC-D1; nPKC-D2; nPKC-mu; nPKC-nu; PKC mu; PKC nu; PKC u; PKC v; PKC-u; PKC-v; PKCmu; PKCu; PKCv; PKD2; protein kinase C mu type; protein kinase C nu type; protein kinase C, mu; protein kinase C, nu; protein kinase D; protein kinase EPK2; unnamed protein product

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Gene Aliases: 4930557O20Rik; 5730497N19Rik; CHDED; EPK2; HSPC187; nPKC-D1; nPKC-D2; nPKC-mu; nPKC-NU; PKC-MU; PKC-NU; PKCM; Pkcnu; PKD; PKD1; PKD2; PKD3; PRKCM; PRKCN; RGD1308054

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UniProt ID: (Human) Q15139, (Human) Q9BZL6, (Human) O94806, (Mouse) Q62101, (Rat) Q9WTQ1, (Rat) Q5XIS9, (Mouse) Q8BZ03, (Mouse) Q8K1Y2

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Entrez Gene ID: (Human) 5587, (Human) 25865, (Human) 23683, (Mouse) 18760, (Rat) 85421, (Rat) 292658, (Mouse) 101540, (Mouse) 75292, (Rat) 313834

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Function(s)
protein kinase activity protein serine/threonine kinase activity protein kinase C activity calcium-independent protein kinase C activity protein kinase C binding protein binding ATP binding kinase activity heat shock protein binding identical protein binding protein serine kinase activity phosphatidylinositol 3-kinase activator activity nucleotide binding
Process(es)
positive regulation of endothelial cell proliferation protein phosphorylation phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of endothelial cell migration sphingolipid biosynthetic process positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of interleukin-2 production positive regulation of interleukin-8 production intracellular signal transduction cellular response to vascular endothelial growth factor stimulus positive regulation of blood vessel endothelial cell migration positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of angiogenesis positive regulation of cell adhesion positive regulation of transcription from RNA polymerase II promoter vascular endothelial growth factor receptor signaling pathway T cell receptor signaling pathway positive regulation of T cell receptor signaling pathway endothelial tube morphogenesis regulation of T cell apoptotic process positive regulation of ERK1 and ERK2 cascade positive regulation of DNA biosynthetic process positive regulation of endothelial cell chemotaxis Golgi organization signal transduction integrin-mediated signaling pathway positive regulation of autophagy positive regulation of gene expression regulation of keratinocyte proliferation positive regulation of neuron projection development regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril cellular response to amino acid starvation cellular response to oxidative stress positive regulation of protein import into nucleus positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of osteoblast differentiation positive regulation of cell size negative regulation of endocytosis protein autophosphorylation positive regulation of protein export from nucleus Golgi vesicle transport defense response to Gram-negative bacterium positive regulation of protein kinase B signaling positive regulation of sarcomere organization transepithelial transport cellular response to hydroperoxide response to norepinephrine cellular response to norepinephrine stimulus positive regulation of peptide hormone secretion positive regulation of NLRP3 inflammasome complex assembly positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway cellular response to angiotensin cellular response to phorbol 13-acetate 12-myristate cellular response to endothelin regulation of integrin-mediated signaling pathway positive regulation of cell communication positive regulation of signaling positive regulation of peptidyl-serine phosphorylation cell-cell adhesion mediated by cadherin regulation of release of sequestered calcium ion into cytosol
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