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Invitrogen

Phospho-PKC alpha/beta-2 (Thr638, Thr641) Recombinant Rabbit Monoclonal Antibody (8D8L5)

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Phospho-PKC alpha/beta-2 (Thr638, Thr641) Recombinant Rabbit Monoclonal Antibody (8D8L5)

Product Details

MA5-55521

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:7,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

8D8L5

Immunogen

A synthetic phosphorylated peptide around T638 of human PRKCA.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.69 mg/mL

Amount

69 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

RRID

AB_3667760

Target Information

Protein Kinase c alpha (PKC alpha) is an 77 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/ threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions including proliferation, differentiation, development, migration, cell cell adhesion, cell extracellular matrix adhesion, and solute transport. The activation loop threonine (threonine 497 in PKC alpha) of conventional PKCs is phosphorylated by phosphoinositide dependent kinase 1 (PDK1). This phosphorylation is necessary for the autophosphorylation of threonine 638 in the carboxy terminus of PKC alpha, a step that is critical for regulating the rate of PKC alpha dephosphorylation and inactivation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AAG6; aging-associated gene 6; PKC-A; PKC-B; PRKC Pan; Protein kinase C alpha type; protein kinase C alpha-polypeptide; Protein kinase C beta type; protein kinase C, beta 1 polypeptide; unnamed protein product

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Gene Aliases: AAG6; PKC-alpha; PKC-beta; PKCA; PKCalpha; PKCB; PKCbeta; PKCI(2); PKCI+/-; PRKACA; PRKCA; PRKCB; PRKCB1; PRKCB2

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UniProt ID: (Human) P17252, (Human) P05771

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Entrez Gene ID: (Human) 5578, (Human) 5579

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein kinase C activity calcium-dependent protein kinase C activity receptor binding integrin binding protein binding ATP binding zinc ion binding kinase activity transferase activity enzyme binding diacylglycerol binding histone kinase activity (H3-T6 specific) metal ion binding protein serine kinase activity chromatin binding transcription coactivator activity protein kinase C binding calcium channel regulator activity histone binding androgen receptor binding
Process(es)
adaptive immune response immune system process chromatin organization chromatin remodeling regulation of transcription from RNA polymerase II promoter protein phosphorylation calcium ion transport cellular calcium ion homeostasis apoptotic process mitotic nuclear envelope disassembly signal transduction phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway regulation of glucose transport negative regulation of glucose transport positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of insulin secretion intracellular signal transduction B cell activation lipoprotein transport positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of angiogenesis positive regulation of transcription, DNA-templated negative regulation of insulin receptor signaling pathway B cell receptor signaling pathway regulation of transport protein kinase C signaling cellular response to carbohydrate stimulus presynaptic modulation of chemical synaptic transmission regulation of synaptic vesicle exocytosis response to reactive oxygen species angiogenesis positive regulation of endothelial cell proliferation desmosome assembly cell adhesion learning or memory response to mechanical stimulus response to toxic substance positive regulation of signal transduction positive regulation of endothelial cell migration positive regulation of cardiac muscle hypertrophy negative regulation of translation central nervous system neuron axonogenesis signal transduction involved in regulation of gene expression positive regulation of cell migration positive regulation of lipopolysaccharide-mediated signaling pathway response to estradiol negative regulation of glial cell apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process response to peptide hormone regulation of mRNA stability protein kinase B signaling positive regulation of blood vessel endothelial cell migration response to ethanol positive regulation of macrophage differentiation positive regulation of bone resorption positive regulation of cell adhesion positive regulation of exocytosis positive regulation of mitotic cell cycle positive regulation of smooth muscle cell proliferation response to corticosterone positive regulation of protein kinase B signaling positive regulation of synapse assembly renal sodium ion absorption positive regulation of ERK1 and ERK2 cascade response to interleukin-1 regulation of platelet aggregation apoptotic signaling pathway positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway positive regulation of angiotensin-activated signaling pathway negative regulation of cytokine production involved in inflammatory response positive regulation of cytokine production involved in inflammatory response response to phorbol 13-acetate 12-myristate positive regulation of dense core granule biogenesis
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