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Invitrogen
PKD2 Monoclonal Antibody (K49022_2E5)
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FIGURE: 1 / 2
PKD2 Antibody (MA5-55690) in IHC (P)
Immunohistochemistry analysis of PKD2 in paraffin-embedded kidney tissue. Sample was incubated with PKD2 monoclonal antibody (Product # MA5-55690) at a dilution of 1 µg/mL (RT, 1 hour). Antigen was retrieved through addition of boiling Tris/EDTA buffer pH 9 in a pressure cooker for 3 min. Endogenous peroxidase activity was quenched by incubating the sections with 3% H2O2 for 30 min at room temperature. Poly... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-55690
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
K49022_2E5
Immunogen
Recombinant human PKD2 (immunogen range is 701-950).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
50 µg
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
Product Specific Information
Sequence of this protein is as follows: SDLIRKGYHK ALVKLKLKKN TVDDISESLR QGGGKLNFDE LRQDLKGKGH TDAEIEAIFT KYDQDGDQEL TEHEHQQMRD DLEKEREDLD LDHSSLPRPM SSRSFPRSLD DSEEDDDEDS GHSSRRRGSI SSGVSYEEFQ VLVRRVDRME HSIGSIVSKI DAVIVKLEIM ERAKLKRREV LGRLLDGVAE DERLGRDSEI HREQMERLVR EELERWESDD AASQISHGLG TPVGLNGQPR PRSSRPSSSQ
Target Information
This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. The encoded protein may function in renal tubular development, morphology, and function, and may modulate intracellular calcium homoeostasis and other signal transduction pathways. This protein interacts with polycystin 1 to produce cation-permeable currents. Mutations in this gene have been associated with autosomal dominant polycystic kidney disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: autosomal dominant polycystic kidney disease type II; autosomal dominant polycystic kidney disease type II protein; PKD2; polycystic kidney disease 2 (autosomal dominant); polycystic kidney disease 2 protein homolog; transient receptor potential cation channel subfamily P member 2; unnamed protein product
Gene Aliases: APKD2; C030034P18Rik; Pc-2; PC2; PKD4; TRPP2
UniProt ID: (Human) Q13563, (Mouse) O35245
Entrez Gene ID: (Human) 5311, (Mouse) 18764
receptor binding
voltage-gated ion channel activity
voltage-gated calcium channel activity
voltage-gated sodium channel activity
voltage-gated potassium channel activity
cation channel activity
calcium channel activity
potassium channel activity
sodium channel activity
calcium ion binding
protein binding
cytoskeletal protein binding
channel activity
outward rectifier potassium channel activity
voltage-gated cation channel activity
identical protein binding
protein homodimerization activity
actinin binding
HLH domain binding
ion channel binding
calcium-induced calcium release activity
ATPase binding
phosphoprotein binding
transcription regulator inhibitor activity
muscle alpha-actinin binding
alpha-actinin binding
branching involved in ureteric bud morphogenesis
kidney development
liver development
embryonic placenta development
heart looping
detection of nodal flow
potassium ion transport
sodium ion transport
calcium ion transport
cell surface receptor signaling pathway
JAK-STAT cascade
determination of left/right symmetry
heart development
negative regulation of cell proliferation
positive regulation of gene expression
Wnt signaling pathway
calcium-mediated signaling
spinal cord development
neural tube development
cellular response to reactive oxygen species
metanephric part of ureteric bud development
sodium ion transmembrane transport
aorta development
regulation of cell proliferation
chordate embryonic development
cilium organization
positive regulation of nitric oxide biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
embryonic organ development
detection of mechanical stimulus
release of sequestered calcium ion into cytosol
protein tetramerization
protein homotetramerization
protein heterotetramerization
centrosome duplication
regulation of cell cycle
transmembrane transport
placenta blood vessel development
renal tubule morphogenesis
renal artery morphogenesis
calcium ion transmembrane transport
cellular response to calcium ion
cellular response to cAMP
cellular response to hydrostatic pressure
cellular response to osmotic stress
cellular response to fluid shear stress
potassium ion transmembrane transport
determination of liver left/right asymmetry
metanephric mesenchyme development
mesonephric tubule development
mesonephric duct development
metanephric smooth muscle tissue development
metanephric cortex development
metanephric ascending thin limb development
metanephric cortical collecting duct development
metanephric distal tubule development
metanephric S-shaped body morphogenesis
regulation of calcium ion import
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
negative regulation of G1/S transition of mitotic cell cycle
cellular calcium ion homeostasis
positive regulation of cytosolic calcium ion concentration
detection of stimulus
negative regulation of ryanodine-sensitive calcium-release channel activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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