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Invitrogen

TLR3 (CD283) (Biosimilar) Recombinant Human Monoclonal Antibody

View all (35) TLR3 (CD283) antibodies

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Product Details

MA5-59171

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

Assay-dependent
-

ELISA (ELISA)

Assay-dependent
-

Functional Assay (Functional)

Assay-dependent
-

Surface plasmon resonance (SPR)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Human / IgG2SA

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Dry ice (international)

RRID

AB_3682189

Product Specific Information

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.

This antibody can also be cross referenced by the term CNTO5429.

Target Information

TLR3 (Toll-like receptor 3, CD283) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from drosophila to humans and share structural and functional similarities. TLRs recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR3 is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. TLR3 recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. Further, TLR3 may play a role in host defense against viruses, and the use of alternative polyadenylation sites to generate different length transcripts has been noted for the TLR3 gene. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. TLR3 is the only human TLR which does not utilize MyD88 as an adaptor molecule instead utilizing TRIF in a signaling path which results in downstream activation of IRF-3 and NF-kB. TLR3 activation leads not only to Type I interferon induction but also to other inflammatory cytokines which result in DC maturation. TLR3 is known to recognize viral double-stranded (ds) RNA, a molecular pattern associated with viral infection. Recently it has been shown to recognize viruses such as Influenza A and West Nile Virus and can mediate entry of at least West Nile Virus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD283; TLR 3; TLR3; Toll-like receptor 3; unnamed protein product

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Gene Aliases: CD283; IIAE2; IMD83; TLR3

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UniProt ID: (Human) O15455

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Entrez Gene ID: (Human) 7098

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Function(s)
RNA binding double-stranded RNA binding transmembrane signaling receptor activity protein binding signaling receptor activity pattern recognition receptor activity identical protein binding ubiquitin-like protein ligase binding
Process(es)
MAPK cascade microglial cell activation toll-like receptor signaling pathway immune system process positive regulation of immune system process regulation of dendritic cell cytokine production defense response inflammatory response hyperosmotic response signal transduction activation of NF-kappaB-inducing kinase activity JNK cascade male gonad development detection of virus response to virus positive regulation of gene expression positive regulation of type I interferon production positive regulation of chemokine production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-gamma production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production toll-like receptor 3 signaling pathway regulation of toll-like receptor 3 signaling pathway type III interferon production positive regulation of type III interferon production cellular response to interferon-beta defense response to bacterium positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process response to exogenous dsRNA response to dsRNA innate immune response negative regulation of osteoclast differentiation positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade positive regulation of inflammatory response defense response to virus positive regulation of macrophage cytokine production cellular response to mechanical stimulus cellular response to interferon-gamma cellular response to exogenous dsRNA cellular response to xenobiotic stimulus inflammatory response to wounding extrinsic apoptotic signaling pathway necroptotic signaling pathway cellular response to virus intracellular signaling cassette positive regulation of cytokine production involved in inflammatory response
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