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Invitrogen
Mycophenolic acid Recombinant Mouse Monoclonal Antibody (5E8)
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FIGURE: 1 / 1
Mycophenolic acid Antibody (MA566406) in SDS-PAGE
SDS-PAGE characterization of Mycophenolic acid under reducing conditions. Lane M: Protein marker (kDa); Lane MPA: Purified Mycophenolic acid Recombinant Monoclonal (Product # MA566406). Mycophenolic acid showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-346.
Product Details
MA566406
Product Specifications
Species Reactivity
Chemical
Host/Isotype
Mouse
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
5E8
Immunogen
Conjugate of MPA hapten and KLH.
Conjugate
Form
Liquid
Concentration
4.1 mg/mL
Amount
200 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Mycophenolic acid (MPA) is a potent immunosuppressive agent primarily used in organ transplantation and treatment of autoimmune diseases. It is a natural product derived from the fungus Penicillium brevicompactum and was the first antibiotic to be isolated and crystallized. MPA functions by inhibiting inosine monophosphate dehydrogenase, a key enzyme in the de novo synthesis of purine nucleotides, thereby suppressing lymphocyte proliferation. The biosynthesis of MPA involves compartmentalized pathways within the fungal cells, highlighting its complex structural features, including a 6-alkyl-2,4-dihydroxybenzoate moiety. Recent studies have explored novel derivatives of MPA, aiming to enhance its cytotoxic and antimicrobial activities, which have shown promising results against various cell lines. The development of biosimilars for MPA is supported by the FDA's bioequivalence standards, offering cost-effective alternatives for immunosuppressive therapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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