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Invitrogen

Phospho-Synaptotagmin 1 (Thr202) Polyclonal Antibody

View all (38) Synaptotagmin 1 antibodies

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Phospho-Synaptotagmin 1 (Thr202) Polyclonal Antibody

Product Details

P21956

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunohistochemistry (IHC)

Assay-dependent
-
Product Specifications

Species Reactivity

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr202 of synaptotagmin.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

purified

Storage buffer

HEPES, pH 7.5, with 100µg/mL BSA, 0.15M NaCl, 50% glycerol

Contains

no preservative

Storage conditions

Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2539838

Target Information

Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein that is widely expressed throughout the CNS and is generally thought to act as the Ca2+ sensor in the regulation of exocytosis and neurotransmitter release. Studies indicate that synaptotagmin's Ca2+ mediated binding of SNAP25 is essential for the Ca2+ dependent triggering of membrane. It has been demonstrated that discrete residues within the c(2)b binding domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size. Synaptotagmin 1 may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Further, Synaptotagmin 1 binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has been reported. Synaptotagmin 1 can also bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Diseases associated with the dysfunction of Synaptotagmin 1 include food-borne botulism and infant botulism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZp781D2042; FLJ42519; SV DKFZp781D2042; SV SYT; Syb1; synaptotagmin 2; synaptotagmin I; Synaptotagmin II; Synaptotagmin XI; Synaptotagmin-2; SYT2; sytI; SytII

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Gene Aliases: P65

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UniProt ID: (Rat) P21707

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Entrez Gene ID: (Rat) 25716

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Function(s)
SNARE binding phosphatidylserine binding calcium ion binding protein binding calmodulin binding phospholipid binding calcium-dependent phospholipid binding phosphatidylinositol-4,5-bisphosphate binding lipid binding syntaxin-1 binding syntaxin binding clathrin binding syntaxin-3 binding identical protein binding protein heterodimerization activity calcium-dependent protein binding low-density lipoprotein particle receptor binding calcium ion sensor activity molecular condensate scaffold activity
Process(es)
detection of calcium ion drug transmembrane transport vesicle fusion neurotransmitter secretion regulation of dopamine secretion vesicle organization synaptic vesicle exocytosis vesicle-mediated transport calcium ion regulated exocytosis regulation of calcium ion-dependent exocytosis regulation of endocytosis regulation of vesicle fusion positive regulation of vesicle fusion synaptic vesicle fusion to presynaptic active zone membrane positive regulation of dopamine secretion synaptic vesicle recycling regulated exocytosis positive regulation of calcium ion-dependent exocytosis negative regulation of neurotransmitter secretion calcium ion-regulated exocytosis of neurotransmitter positive regulation of synaptic transmission protein insertion into membrane protein heterooligomerization response to calcium ion regulation of synaptic transmission, glutamatergic inhibitory postsynaptic potential calcium activated phospholipid scrambling spontaneous neurotransmitter secretion cellular response to calcium ion synchronous neurotransmitter secretion fast, calcium ion-dependent exocytosis of neurotransmitter calcium-dependent activation of synaptic vesicle fusion synaptic vesicle cycle membraneless organelle assembly regulation of calcium-dependent activation of synaptic vesicle fusion positive regulation of calcium ion-dependent exocytosis of neurotransmitter regulation of regulated secretory pathway positive regulation of dendrite extension regulation of synaptic vesicle exocytosis
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