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Invitrogen
PP1 alpha Polyclonal Antibody
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FIGURE: 1 / 2
PP1 alpha Antibody (PA1-12376) in ICC/IF
Immunofluorescence analysis of PP1 alpha was performed using 70 percent confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with PP1 alpha Polyclonal Antibody (Product # PA1-12376) at 5 µg/mL in 0.1% BSA, incubated at 4 degree cels... View More
Product Details
PA1-12376
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 317-330 of PP1 alpha catalytic subunit.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
PBS
Contains
0.08% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody recognizes the recombinant pp1 alpha, pp1 beta, pp1 gamma 1, and pp1 gamma 2 forms.
Target Information
This gene encodes a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum. The protein shows sequence similarity to the protein disulfide isomerase family. However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GADD34; MGC15877; MGC1674; PP-1A; protein phosphatase 1, catalytic subunit, alpha isoform; protein phosphatase 1, catalytic subunit, alpha isozyme; protein phosphatase I alpha subunit (PPPIA) (EC 3.1.3.16); Protein phosphatase type 1 alpha, catalytic subunit; protein phosphatase-1d; serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit; Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; testicular tissue protein Li 155; unnamed protein product
Gene Aliases: dism2; PP-1A; PP1A; PP1alpha; PPP1A; Ppp1c; PPP1CA
UniProt ID: (Human) P62136, (Bovine) Q3T0E7, (Mouse) P62137, (Rat) P62138
Entrez Gene ID: (Human) 5499, (Bovine) 516175, (Mouse) 19045, (Rat) 24668
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
iron ion binding
protein binding
protein phosphatase 1 binding
hydrolase activity
phosphatase activity
ribonucleoprotein complex binding
macromolecular complex binding
metal ion binding
transition metal ion binding
cadherin binding involved in cell-cell adhesion
RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
protein complex binding
protein phosphatase
telomere maintenance
promoter clearance from RNA polymerase II promoter
glycogen metabolic process
regulation of glycogen biosynthetic process
regulation of glycogen catabolic process
transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
protein dephosphorylation
response to lead ion
dephosphorylation
lung development
circadian regulation of gene expression
positive regulation of transcription elongation from RNA polymerase II promoter
negative regulation of transcription elongation from RNA polymerase II promoter
regulation of circadian rhythm
entrainment of circadian clock by photoperiod
telomere maintenance in response to DNA damage
regulation of translational initiation in response to stress
positive regulation of glycogen biosynthetic process
branching morphogenesis of an epithelial tube
protein stabilization
cell division
regulation of canonical Wnt signaling pathway
double-strand break repair via alternative nonhomologous end joining
cell-cell adhesion
positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
cell cycle
carbohydrate metabolic process
regulation of translation
female meiotic division
cellular process
rhythmic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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