Search
Invitrogen
IGF2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-110730
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human IGF2. Recombinant protein control fragment (Product #RP-103757).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TLQFVCGDRG FYFSRPASRV SRRSRGIVEE CCFRSCDLAL LETYCATPAK SERDVSTPPT VLPDNFPRYP VGKFFQYDTW KQSTQRLRRG LPALLRARRG HVLAKELEAF REAKRHRPLI ALPTQD
Highest antigen sequence indentity to the following orthologs: Rat - 86%, Mouse - 86%.
Target Information
The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: FLJ22066; FLJ44734; GIG44; H-IGF-2; IGF; IGF-II; Insulin like growth factor; Insulin-like growth factor 2; insulin-like growth factor 2 (somatomedin A); Insulin-like growth factor II; insulin-like growth factor II precursor; insulin-like growth factor type 2; insulin-like growth factor-II; preproinsulin-like growth factor II, domains A-E; preptin; somatomedin A; Somatomedin-A; T3M-11-derived growth factor; unnamed protein product
Gene Aliases: C11orf43; GRDF; IGF-2; IGF-II; IGF2; PP1446; PP9974; SRS3
UniProt ID: (Human) P01344
Entrez Gene ID: (Human) 3481
negative regulation of transcription from RNA polymerase II promoter
ossification
osteoblast differentiation
in utero embryonic development
embryonic placenta development
glucose metabolic process
regulation of transcription, DNA-templated
positive regulation of cell proliferation
insulin receptor signaling pathway
organ morphogenesis
exocrine pancreas development
positive regulation of multicellular organism growth
positive regulation of activated T cell proliferation
positive regulation of MAPK cascade
positive regulation of glycogen biosynthetic process
positive regulation of mitotic nuclear division
positive regulation of transcription from RNA polymerase II promoter
positive regulation of organ growth
positive regulation of insulin receptor signaling pathway
insulin-like growth factor receptor signaling pathway
positive regulation of skeletal muscle tissue growth
striated muscle cell differentiation
regulation of muscle cell differentiation
negative regulation of muscle cell differentiation
positive regulation of cell division
positive regulation of protein kinase B signaling
embryonic placenta morphogenesis
genetic imprinting
positive regulation of vascular endothelial cell proliferation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support