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Invitrogen
BARD1 Polyclonal Antibody
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Product Details
PA5-65149
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human BARD1. Recombinant protein control fragment (Product #RP-105901).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RRDGPLVLIGS GLSSEQQKML SELAVILKAK KYTEFDSTVT HVVVPGDAVQ STLKCMLGIL NGCWILKFEW VKACLRRKVC EQEEKYEI
Highest antigen sequence identity to the following orthologs - mouse 76%, rat 73%.
Target Information
This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BARD 1; BARD-1; BRCA1-associated RING domain gene 1; BRCA1-associated RING domain protein 1; RING-type E3 ubiquitin transferase BARD1; unnamed protein product
Gene Aliases: BARD1
UniProt ID: (Human) Q99728
Entrez Gene ID: (Human) 580
RNA binding
ubiquitin-protein transferase activity
protein binding
zinc ion binding
transferase activity
kinase binding
protein homodimerization activity
metal ion binding
protein heterodimerization activity
ubiquitin protein ligase activity
ubiquitinated histone binding
histone H2AK127 ubiquitin ligase activity
histone H2AK129 ubiquitin ligase activity
tissue homeostasis
DNA repair
regulation of DNA repair
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
protein ubiquitination
negative regulation of mRNA 3'-end processing
reciprocal DNA recombination
regulation of phosphorylation
positive regulation of apoptotic process
negative regulation of apoptotic process
mitotic G2/M transition checkpoint
positive regulation of protein catabolic process
negative regulation of cell cycle
negative regulation of protein export from nucleus
regulation of cell cycle
cellular response to ionizing radiation
protein K6-linked ubiquitination
DNA strand resection involved in replication fork processing
regulation of DNA damage checkpoint
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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