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Invitrogen
S100B Polyclonal Antibody
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FIGURE: 1 / 13
S100B Antibody (PA5-78161) in ICC/IF
S100B Polyclonal Antibody detects S100 beta protein at glia cells by immunofluorescent analysis. Sample: DIV10 rat E18 primary cortical neuron and glia cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: S100 beta stained by S100B Polyclonal Antibody (Product # PA5-78161) diluted at 1:500. Red: Tau, stained by Phospho-Tau (Ser262) Polyclonal Antibody [GT287]diluted at 1:500. Blue: Fluoroshield with DAPI .
Product Details
PA5-78161
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fish,
Human,
Mouse,
Rodent,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full length human S100 beta Recombinant protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.14 mg/mL
Amount
14 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: V5-human S100B-transfected 293T, A375, mouse brain, rat brain
Predicted Reactivity: Rabbit (100%), Chicken (84%), Rhesus Monkey (98%), Bovine (96%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
S100B is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells and are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100B may function in neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Protein S100-B; S-100 calcium-binding protein, beta chain; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium binding protein beta (neural); S100 calcium-binding protein B; S100 calcium-binding protein beta (neural); S100 calcium-binding protein, beta (neural); S100 protein beta chain; S100 protein, beta polypeptide, neural; S100B
Gene Aliases: AI850290; Bpb; NEF; S100; S100-B; S100B; S100beta; S100P
UniProt ID: (Human) P04271, (Mouse) P50114, (Rat) P04631
Entrez Gene ID: (Human) 6285, (Mouse) 20203, (Rat) 25742
cell adhesion
axonogenesis
central nervous system development
learning or memory
memory
positive regulation of cell proliferation
regulation of cell shape
positive regulation of myelination
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to ethanol
positive regulation of neuron differentiation
regulation of neuronal synaptic plasticity
astrocyte differentiation
positive regulation of synaptic transmission
response to glucocorticoid
response to methylmercury
long-term synaptic potentiation
cellular response to hypoxia
response to anesthetic
sympathetic neuron projection extension
neuron projection extension
adaptive thermogenesis
negative regulation of skeletal muscle cell differentiation
energy reserve metabolic process
cellular calcium ion homeostasis
regulation of cytokine biosynthetic process
regulation of long-term neuronal synaptic plasticity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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