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Invitrogen
PSMA Polyclonal Antibody
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Product Details
PA5-82398
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FOLH1. Recombinant protein control fragment (Product #RP-90005).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ADYFAPGVKS YPDGWNLPGG GVQRGNILNL NGAGDPLTPG YPANEYAYRR GIAEAVGLPS IPVHPIGYYD AQKLLEKMGG SAPPDSSWRG SLKVPYNVGP GFTGNF
Highest antigen sequence indentity to the following orthologs: Rat - 90%, Mouse - 86%.
Target Information
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cell growth-inhibiting gene 27 protein; FGCP; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; GCPII; GIG27; glutamate carboxylase II; Glutamate carboxypeptidase 2; Glutamate carboxypeptidase II; glutamate carboxypeptidase II; folate hydrolase; Membrane glutamate carboxypeptidase; mGCP; N-acetylated alpha-linked acidic dipeptidase 1; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; prostate specific membrane antigen; Prostate-specific membrane antigen; PSM; PSM-E; PSM-F; Pteroylpoly-gamma-glutamate carboxypeptidase; unnamed protein product
Gene Aliases: FGCP; FOLH; FOLH1; GCP2; GCPII; GIG27; mGCP; NAALAD1; PSM; PSMA
UniProt ID: (Human) Q04609
Entrez Gene ID: (Human) 2346
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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