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Invitrogen
SLC15A1 Polyclonal Antibody
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FIGURE: 1 / 5
SLC15A1 Antibody (PA5-101733) in ICC/IF
Immunofluorescent analysis of SLC15A1 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and SLC15A1 polyclonal antibody (Product # PA5-101733) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-101733
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SLC15A1(Accession P46059), corresponding to amino acid residues K224-I274.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SLC15A1.
Target Information
In mammalian small intestine, the proton-coupled peptide transporter (PEPT) is responsible for the absorption of small peptides arising from digestion of dietary proteins. PEPT1, a hydrogen ion/peptide cotransporter, transports dipeptides and tripeptides, but not free amino acids or peptides with more than three amino acid residues. Its driving force for uphill transport requires proton binding and the presence of an inside-negative membrane potential. PEPT1 is 708 amino acid protein that contains 12 putative membrane-spanning domains. PEPT1 is expressed in Caco-2 cells. PEPT1 seems to play important roles in nutritional and pharmacological therapies. The mammalian kidney expresses a proton-coupled peptide transporter, PEPT2, that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Caco-2 oligopeptide transporter; intestinal H(+)/peptide cotransporter; intestinal H+/peptide cotransporter; intestinal peptide transporter PEPT1; macrophage oligopeptide transporter PEPT1; peptide transporter 1; pineal gland-specific PEPT1; proton-coupled dipeptide cotransporter; SLC15A1; solute carrier family 15 (oligopeptide transporter), member 1; unnamed protein product
Gene Aliases: D630032F02; HPECT1; HPEPT1; PECT1; PEPT1
UniProt ID: (Human) P46059, (Rat) P51574, (Mouse) Q9JIP7
Entrez Gene ID: (Human) 6564, (Rat) 117261, (Mouse) 56643
proton-dependent oligopeptide secondary active transmembrane transporter activity
peptide:proton symporter activity
transmembrane transporter activity
oligopeptide transmembrane transporter activity
tripeptide transporter activity
dipeptide transmembrane transporter activity
channel inhibitor activity
oligopeptide transport
oligopeptide transmembrane transport
transmembrane transport
dipeptide import across plasma membrane
tripeptide import across plasma membrane
hydrogen ion transmembrane transport
tripeptide transport
negative regulation of amino acid transport
metanephric proximal tubule development
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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