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Invitrogen
BCAR3 Polyclonal Antibody
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FIGURE: 1 / 2
BCAR3 Antibody (PA5-104511) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded BCAR3 in human Breast cancer tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with BCAR3 polyclonal antibody (Product # PA5-104511) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Product Details
PA5-104511
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human BCAR3(Accession O75815), corresponding to amino acid residues M774-E824.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total BCAR3.
Target Information
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BCAR3 adapter protein, NSP family member; BCAR3, NSP family adaptor protein; breast cancer anti-estrogen resistance 3; Breast cancer anti-estrogen resistance protein 3; Breast cancer anti-estrogen resistance protein 3 homolog; breast cancer antiestrogen resistance 3 protein; dJ1033H22.2 (breast cancer anti-estrogen resistance 3); epididymis secretory sperm binding protein; KIAA0554; mig-7; migration inducting gene-7; Novel SH2-containing protein 2; OTTHUMP00000011961; p130Cas-binding protein AND-34; SH2 domain-containing protein 3B; unnamed protein product
Gene Aliases: AND-34; BCAR3; MIG7; NSP2; SH2D3B; UNQ271/PRO308
UniProt ID: (Human) O75815, (Rat) D3ZAZ5
Entrez Gene ID: (Human) 8412, (Rat) 310838
lens morphogenesis in camera-type eye
small GTPase mediated signal transduction
positive regulation of peptidyl-serine phosphorylation
positive regulation of GTPase activity
signal transduction
epidermal growth factor receptor signaling pathway
positive regulation of cell proliferation
insulin receptor signaling pathway
response to xenobiotic stimulus
positive regulation of MAPK cascade
endothelin receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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