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Invitrogen
Phospho-Oxytocin Receptor (Thr235) Polyclonal Antibody
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FIGURE: 1 / 3
Phospho-Oxytocin Receptor (Thr235) Antibody (PA5-105111) in IHC (P)
Immunohistochemistry analysis of Phospho-Oxytocin Receptor (Thr235) in mouse lung tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Phospho-Oxytocin Receptor (Thr235) polyclonal antibody (Product # PA5-105111) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-105111
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human OXTR(Accession P30559), corresponding to amino acid residues around phosphorylated Thr235.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of Oxytocin Receptor only when phosphorylated at Thr235.
Target Information
The oxytocin receptor (OXTR) belongs to the G-protein coupled receptor family. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The receptor is made up of 389 amino acids and has a molecular weight of ~43,000 kDa. The oxytocin-oxytocin receptor system plays an important role as an inducer of uterine contractions during parturition and of milk ejection. Oxytocin receptors are expressed by the myoepithelial cells of the mammary gland, and in both the myometrium and endometrium or the uterus at the end of pregnancy. Additionally, oxytocin receptors are present in the central nervous system, mediating a variety of behaviors, including maternal behavior, bonding, social memory and recognition, sexual and aggressive behaviors, and stress and anxiety.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G-protein coupled receptor; OT-R; oxcytocin receptor; Oxt-r; Oxytocin receptor; unnamed protein product
Gene Aliases: OT-R; OTR; OTR1; OXTR
UniProt ID: (Human) P30559, (Mouse) P97926, (Rat) P70536
Entrez Gene ID: (Human) 5021, (Mouse) 18430, (Rat) 25342
regulation of systemic arterial blood pressure by vasopressin
system process
muscle contraction
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
female pregnancy
lactation
cellular response to hormone stimulus
positive regulation of blood pressure
positive regulation of vasoconstriction
maternal process involved in parturition
regulation of biological quality
positive regulation of cold-induced thermogenesis
suckling behavior
response to amphetamine
positive regulation of cytosolic calcium ion concentration
memory
positive regulation of norepinephrine secretion
sleep
positive regulation of synaptic transmission, GABAergic
response to anoxia
social behavior
maternal behavior
sperm ejaculation
eating behavior
regulation of digestive system process
response to steroid hormone
positive regulation of synapse assembly
positive regulation of synaptic transmission, glutamatergic
positive regulation of penile erection
negative regulation of gastric acid secretion
ERK1 and ERK2 cascade
positive regulation of uterine smooth muscle contraction
response to peptide
heart development
response to organic cyclic compound
telencephalon development
response to estradiol
response to progesterone
response to cytokine
response to cocaine
response to drug
response to peptide hormone
estrous cycle
digestive tract development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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