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Invitrogen

Phospho-EphA4 (Tyr596) Polyclonal Antibody

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Phospho-EphA4 (Tyr596) Polyclonal Antibody

Product Details

PA5-105118

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human EPHA4(Accession P54764), corresponding to amino acid residues around phosphorylated Tyr596.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816591

Product Specific Information

Antibody detects endogenous levels of EPHA4 only when phosphorylated at Tyr596.

Target Information

EPHA4 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. EphA4 encodes a protein that binds ephrin-A ligands.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: epa4; EPH-like kinase 8; Eph-related receptor protein tyrosine kinase; receptor protein-tyrosine kinase HEK8; TYRO1 protein tyrosine kinase; tyrosine-protein kinase receptor MPK-3; tyrosine-protein kinase receptor SEK; tyrosine-protein kinase receptor SEK-1; tyrosine-protein kinase TYRO1; unnamed protein product

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Gene Aliases: 2900005C20Rik; Cek8; EK8; HEK8; rb; RGD1560587; SEK; Sek1; TYRO1

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UniProt ID: (Human) P54764, (Mouse) Q03137

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Entrez Gene ID: (Human) 2043, (Mouse) 13838, (Rat) 316539

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Function(s)
beta-amyloid binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity GPI-linked ephrin receptor activity transmembrane-ephrin receptor activity protein binding ATP binding kinase activity PH domain binding identical protein binding ephrin receptor binding DH domain binding protein tyrosine kinase binding nucleotide binding
Process(es)
deadenylation-dependent decapping of nuclear-transcribed mRNA negative regulation of cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway axon guidance adult walking behavior motor neuron axon guidance positive regulation of cell proliferation glial cell migration negative regulation of epithelial to mesenchymal transition negative regulation of neuron projection development negative regulation of translation central nervous system projection neuron axonogenesis corticospinal tract morphogenesis positive regulation of cell migration negative regulation of cell migration adherens junction organization regulation of GTPase activity negative regulation of neuron apoptotic process positive regulation of cell adhesion negative regulation of translational initiation positive regulation of JNK cascade ephrin receptor signaling pathway animal organ development negative regulation of axon regeneration regulation of astrocyte differentiation regulation of axonogenesis positive regulation of dendrite morphogenesis regulation of developmental process synapse organization protein stabilization innervation regulation of dendritic spine morphogenesis negative regulation of ERK1 and ERK2 cascade nephric duct morphogenesis cochlea development fasciculation of sensory neuron axon fasciculation of motor neuron axon neuron projection guidance synapse pruning neuron projection fasciculation membraneless organelle assembly negative regulation of cellular response to hypoxia negative regulation of long-term synaptic potentiation cellular response to oxygen-containing compound positive regulation of beta-amyloid formation positive regulation of intracellular signal transduction positive regulation of amyloid precursor protein catabolic process cellular response to beta-amyloid positive regulation of leukocyte adhesion to arterial endothelial cell regulation of modification of synaptic structure regulation of synapse pruning central nervous system development neuron projection development
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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