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Invitrogen

Phospho-VCP (Ser352) Polyclonal Antibody

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Phospho-VCP (Ser352) Polyclonal Antibody

Product Details

PA5-105188

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human VCP(Accession P55072), corresponding to amino acid residues around phosphorylated Ser352.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816661

Product Specific Information

Antibody detects endogenous levels of VCP only when phosphorylated at Ser352.

Target Information

The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 15S Mg(2+)-ATPase p97 subunit; AAA ATPase p97; homolog of yeast cdc48; Inv protein; or HEL-S-70; p97 atpase; TER ATPase; Transitional endoplasmic reticulum ATPase; unnamed protein product; Valosin-containing protein; VCP

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Gene Aliases: 3110001E05; CDC48; FTDALS6; HEL-220; HEL-S-70; p97; p97/VCP; TERA; VCP

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UniProt ID: (Human) P55072, (Mouse) Q01853, (Rat) P46462

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Entrez Gene ID: (Human) 7415, (Mouse) 269523, (Rat) 116643

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Function(s)
nucleotide binding RNA binding protein binding ATP binding lipid binding hydrolase activity ATPase activity protein phosphatase binding protein domain specific binding polyubiquitin binding ubiquitin protein ligase binding deubiquitinase activator activity K48-linked polyubiquitin binding MHC class I protein binding identical protein binding ADP binding ubiquitin-like protein ligase binding macromolecular complex binding ubiquitin-dependent protein binding BAT3 complex binding ubiquitin-specific protease binding receptor binding protein complex binding poly(A) RNA binding
Process(es)
DNA repair double-strand break repair ubiquitin-dependent protein catabolic process transport ER to Golgi vesicle-mediated transport activation of cysteine-type endopeptidase activity involved in apoptotic process cellular response to DNA damage stimulus protein ubiquitination protein N-linked glycosylation via asparagine viral genome replication translesion synthesis ER-associated ubiquitin-dependent protein catabolic process retrograde protein transport, ER to cytosol positive regulation of protein complex assembly positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein hexamerization positive regulation of protein catabolic process protein homooligomerization aggresome assembly ER-associated misfolded protein catabolic process positive regulation of protein K63-linked deubiquitination positive regulation of Lys63-specific deubiquitinase activity autophagy I-kappaB kinase/NF-kappaB signaling proteasomal protein catabolic process positive regulation of mitochondrial membrane potential macroautophagy NAD metabolic process endoplasmic reticulum unfolded protein response endosome to lysosome transport via multivesicular body sorting pathway cellular response to heat negative regulation of hippo signaling stress granule disassembly interstrand cross-link repair ERAD pathway regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process establishment of protein localization negative regulation of smoothened signaling pathway ATP metabolic process regulation of synapse organization mitotic spindle disassembly endoplasmic reticulum stress-induced pre-emptive quality control cellular response to misfolded protein flavin adenine dinucleotide catabolic process positive regulation of canonical Wnt signaling pathway autophagosome maturation protein-DNA covalent cross-linking repair negative regulation of protein localization to chromatin cytoplasm protein quality control positive regulation of NIK/NF-kappaB signaling regulation of aerobic respiration cellular response to arsenite ion positive regulation of oxidative phosphorylation regulation of protein localization to chromatin positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of ATP biosynthetic process
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