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Invitrogen
Phospho-SHIP2 (Tyr671) Polyclonal Antibody
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FIGURE: 1 / 4
Phospho-SHIP2 (Tyr671) Antibody (PA5-105386) in ICC/IF
Immunocytochemistry analysis of Phospho-SHIP2 (Tyr671) in Hela cells (20 min of 30 µM Forskolin treatment). The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Phospho-SHIP2 (Tyr671) polyclonal antibody (Product # PA5-105386) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated g... View More
Product Details
PA5-105386
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human INPPL1(Accession O15357), corresponding to amino acid residues around phosphorylated Tyr671.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of INPPL1 only when phosphorylated at Tyr671.
Target Information
The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodeling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 51C protein; ablSH3-binding protein; Inositol polyphosphate phosphatase-like protein 1; INPPL-1; NS1; Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2; Protein 51C; PTP2C; SH-PTP2; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SH2 domain-containing inositol-5'-phosphatase 2; SH2-containing inositol phosphatase 2; SHIP-2; SHP-2
Gene Aliases: 51C; INPPL1; OPSMD; SHIP2
UniProt ID: (Human) O15357, (Rat) Q9WVR3, (Mouse) Q6P549
Entrez Gene ID: (Human) 3636, (Rat) 65038, (Mouse) 16332
establishment of mitotic spindle orientation
endochondral ossification
immune system process
glucose metabolic process
lipid metabolic process
phosphatidylinositol biosynthetic process
endocytosis
apoptotic process
actin filament organization
cell adhesion
negative regulation of cell proliferation
post-embryonic development
gene expression
negative regulation of gene expression
response to insulin
regulation of protein localization
protein kinase B signaling
negative regulation of insulin-like growth factor receptor signaling pathway
phosphatidylinositol dephosphorylation
regulation of immune response
ERK1 and ERK2 cascade
ruffle assembly
regulation of actin filament organization
brain development
negative regulation of DNA replication
negative regulation of platelet-derived growth factor receptor signaling pathway
negative regulation of neuron projection development
inositol trisphosphate metabolic process
response to drug
negative regulation of MAP kinase activity
cellular lipid metabolic process
negative regulation of insulin receptor signaling pathway
dephosphorylation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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