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Invitrogen
Phospho-BRCA2 (Ser2095) Polyclonal Antibody
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FIGURE: 1 / 4
Phospho-BRCA2 (Ser2095) Antibody (PA5-105585) in ICC/IF
Immunocytochemistry analysis of Phospho-BRCA2 (Ser2095) in HepG2 cells (4h of LPS treatment). The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Phospho-BRCA2 (Ser2095) polyclonal antibody (Product # PA5-105585) 1:200 and mouse anti-beta tubulin antibody (1:200) for 1 hour at 37°C. An AlexaFluor594 conjugated ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-105585
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human BRCA2(Accession P51587), corresponding to amino acid residues around phosphorylated Ser2095.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of BRCA2 only when phosphorylated at Ser2095.
Target Information
Breast Cancer Type 2 susceptibility protein (BRCA2) is a tumor-suppressor protein reported to be involved in double-strand break repair, homologous recombination and S-phase checkpoint activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: brca 2; brca-2; BRCA1/BRCA2-containing complex, subunit 2; Brca2; BRCA2 DNA repair associated protein; breast and ovarian cancer susceptibility gene, early onset; breast and ovarian cancer susceptibility protein 2; breast cancer 2 tumor suppressor; breast cancer 2, early onset; breast cancer 2, mutation 1, University of Wisconsin-Madison; breast cancer susceptibility protein 2; DNA repair associated; DNA repair-associated BRCA2; FANCB; Fanconi anemia group D1 protein; fanconi anemia group D1 protein homolog; mutant BRCA2; mutant DNA repair-associated protein 2; RP11-298P3.4; transcript variant 1; unnamed protein product
Gene Aliases: BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD; FANCD1; GLM3; PNCA2; RAB163; XRCC11
UniProt ID: (Human) P51587, (Mouse) P97929
Entrez Gene ID: (Human) 675, (Mouse) 12190, (Rat) 360254
protease binding
double-stranded DNA binding
single-stranded DNA binding
histone acetyltransferase activity
protein binding
protein binding, bridging
identical protein binding
gamma-tubulin binding
molecular function inhibitor activity
H3 histone acetyltransferase activity
H4 histone acetyltransferase activity
telomere maintenance via recombination
double-strand break repair via homologous recombination
DNA recombinase assembly
DNA repair
nucleotide-excision repair
double-strand break repair
DNA recombination
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
male meiosis I
negative regulation of mammary gland epithelial cell proliferation
positive regulation of transcription, DNA-templated
centrosome duplication
establishment of protein localization to telomere
cellular response to ionizing radiation
mitotic recombination-dependent replication fork processing
double-strand break repair involved in meiotic recombination
regulation of DNA damage checkpoint
oocyte maturation
inner cell mass cell proliferation
chromatin remodeling
meiosis I
spermatogenesis
brain development
cell proliferation
female gonad development
intrinsic apoptotic signaling pathway in response to DNA damage
response to X-ray
response to UV-C
response to gamma radiation
hemopoiesis
DNA damage response, signal transduction by p53 class mediator
mammary gland development
replication fork processing
homologous chromosome orientation involved in meiotic metaphase I plate congression
regulation of cytokinesis
multicellular organism growth
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
chordate embryonic development
positive regulation of mitotic cell cycle
chromosome organization
cellular senescence
response to nutrient
response to estradiol
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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