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Invitrogen
Phospho-EphA7 (Tyr614) Polyclonal Antibody
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FIGURE: 1 / 2
Phospho-EphA7 (Tyr614) Antibody (PA5-105654) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-EphA7 (Tyr614) in human liver tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-EphA7 (Tyr614) polyclonal antibody (Product # PA5-105654) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Product Details
PA5-105654
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human EPHA7(Accession Q15375), corresponding to amino acid residues around phosphorylated Tyr614.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of EPHA7 only when phosphorylated at Tyr614.
Target Information
EPHA7 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. EPHA7 is involved in embryonic development. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Developmental kinase 1; EBK; EHK-3; EK11; Embryonic brain kinase; epa7; EPH homology kinase 3; Eph homology kinase-3; EPH-like kinase 11; EPHA7-S; Ephrin type-A receptor 7; mDK-1; receptor protein-tyrosine kinase HEK11; tyrosine-protein kinase receptor EHK-3; unnamed protein product
Gene Aliases: Cek11; Ebk; EHK-3; EHK3; EK11; EPHA7; HEK11; Mdk1
UniProt ID: (Human) Q15375, (Mouse) Q61772
Entrez Gene ID: (Human) 2045, (Mouse) 13841
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
ephrin receptor activity
GPI-linked ephrin receptor activity
transmembrane-ephrin receptor activity
protein binding
ATP binding
axon guidance receptor activity
kinase activity
transferase activity
growth factor binding
chemorepellent activity
ephrin receptor binding
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
apoptotic process
transmembrane receptor protein tyrosine kinase signaling pathway
nervous system development
axon guidance
brain development
phosphorylation
regulation of cell-cell adhesion
retinal ganglion cell axon guidance
regulation of protein autophosphorylation
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
ephrin receptor signaling pathway
negative regulation of collateral sprouting
branching morphogenesis of a nerve
regulation of peptidyl-tyrosine phosphorylation
modulation of synaptic transmission
negative chemotaxis
neuron apoptotic process
negative regulation of protein kinase B signaling
negative regulation of synapse assembly
regulation of ERK1 and ERK2 cascade
nephric duct morphogenesis
regulation of postsynapse organization
protein phosphorylation
signal transduction
multicellular organism development
peptidyl-tyrosine phosphorylation
regulation of cysteine-type endopeptidase activity involved in apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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