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Invitrogen

Phospho-MAP2K1/MAP2K2 (Ser212, Ser216) Polyclonal Antibody

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Phospho-MAP2K1/MAP2K2 (Ser212, Ser216) Polyclonal Antibody

Product Details

PA5-105897

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human MAP2K1(Accession Q02750), corresponding to amino acid residues around phosphorylated Ser212.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817296

Product Specific Information

Antibody detects endogenous levels of MEK1/2 only when phosphorylated at Ser212/216.

Target Information

MEK 1 (MAP Kinase Kinase, also known as MKK) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation (Ahn, 1993; Chong et al., 2003). In brain, this pathway also plays a key role in synaptic (Adams and Sweatt, 2002). Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase (Kyriakis et al., 1991; Seger et al., 1991; Crews et al., 1992).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: EC 2.7.12.2; ERK activator kinase 1; ERK activator kinase 2; kinase MEK1; MAP kinase kinase 1; MAP kinase kinase 2; MAP kinase/Erk kinase; MAP kinase/Erk kinase 1; MAPK/ERK kinase 1; MAPK/ERK kinase 2; MAPKK 1; MAPKK 2; MEK 1; MEK 2; MEK-1; MEK-2; MEK2; mitogen-activated protein kinase kinase 2, p45; MP2K1; protein kinase, mitogen activated, kinase 1, p45; protein kinase, mitogen activated, kinase 2, p45; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1); unnamed protein product

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Gene Aliases: CFC3; CFC4; MAPKK1; MAPKK2; MEK1; MEK2; MEKK1; MEL; MK2; MKK1; MKK2; PRKMK1; PRKMK2

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UniProt ID: (Human) Q02750, (Human) P36507, (Mouse) P31938, (Rat) Q01986, (Rat) P36506, (Mouse) Q63932

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Entrez Gene ID: (Human) 5604, (Human) 5605, (Mouse) 26395, (Rat) 170851, (Rat) 58960, (Mouse) 26396

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Function(s)
protein kinase activity protein serine/threonine kinase activity MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity MAP-kinase scaffold activity protein binding ATP binding protein kinase binding protein kinase activator activity small GTPase binding mitogen-activated protein kinase kinase kinase binding protein serine/threonine kinase activator activity macromolecular complex binding scaffold protein binding protein serine kinase activity PDZ domain binding binding, bridging
Process(es)
MAPK cascade positive regulation of gene expression regulation of stress-activated MAPK cascade peptidyl-serine autophosphorylation positive regulation of transcription, DNA-templated ERK1 and ERK2 cascade positive regulation of protein serine/threonine kinase activity regulation of Golgi inheritance regulation of early endosome to late endosome transport regulation of vascular smooth muscle contraction chemotaxis response to oxidative stress signal transduction neuromuscular junction development negative regulation of cell proliferation positive regulation of autophagy negative regulation of gene expression Schwann cell development neuron differentiation positive regulation of cell migration melanosome transport positive regulation of transcription elongation from RNA polymerase II promoter negative regulation of homotypic cell-cell adhesion ERBB signaling pathway ERBB2-ERBB3 signaling pathway myelination positive regulation of MAPK cascade positive regulation of muscle contraction vesicle transport along microtubule insulin-like growth factor receptor signaling pathway Golgi inheritance response to axon injury neuron projection morphogenesis response to glucocorticoid triglyceride homeostasis regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular senescence regulation of neurotransmitter receptor localization to postsynaptic specialization membrane negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway positive regulation of ATP biosynthetic process protein phosphorylation heart development insulin receptor signaling pathway cerebellar cortex formation keratinocyte differentiation thyroid gland development positive regulation of GTPase activity positive regulation of cell differentiation positive regulation of Ras protein signal transduction thymus development regulation of axon regeneration cell motility positive regulation of axonogenesis Bergmann glial cell differentiation face development lung morphogenesis trachea formation epithelial cell proliferation involved in lung morphogenesis placenta blood vessel development labyrinthine layer development intracellular signal transduction response to ischemia peptidyl-tyrosine phosphorylation positive regulation of cell motility
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