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Invitrogen

Phospho-NFATC1 (Ser172) Polyclonal Antibody

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Phospho-NFATC1 (Ser172) Polyclonal Antibody

Product Details

PA5-106018

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human NFATC1(Accession O95644), corresponding to amino acid residues around phosphorylated Ser172.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817417

Product Specific Information

Antibody detects endogenous levels of NFAT2 only when phosphorylated at Ser172.

Target Information

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: MGC138448; NF-ATc1; NFAT tra; NFAT trans; NFAT transcription complex cytosolic component; nuclear factor of activated T cells; nuclear factor of activated T-cells 'c'; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1; transcription factor; transcription factor NF-ATc; unnamed protein product

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Gene Aliases: 2210017P03Rik; NF-ATC; NF-ATc1.2; NFAT2; NFATc; Nfatcb

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UniProt ID: (Human) O95644

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Entrez Gene ID: (Human) 4772, (Rat) 100361818, (Mouse) 18018

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding FK506 binding protein phosphatase 2B binding mitogen-activated protein kinase p38 binding RNA polymerase II sequence-specific DNA binding transcription factor binding sequence-specific double-stranded DNA binding transcription coactivator binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding chromatin binding sequence-specific DNA binding DNA-binding transcription factor binding RNA polymerase II regulatory region sequence-specific DNA binding
Process(es)
aortic valve morphogenesis pulmonary valve morphogenesis regulation of transcription, DNA-templated negative regulation of Wnt signaling pathway calcineurin-NFAT signaling cascade intracellular signal transduction positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of inflammatory response negative regulation of vascular smooth muscle cell differentiation G1/S transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter epithelial to mesenchymal transition lymphangiogenesis B-1a B cell differentiation heart valve development aortic valve development pulmonary valve development heart valve morphogenesis endocardial cushion development regulation of transcription from RNA polymerase II promoter calcium ion transport heart development gene expression positive regulation of gene expression response to muscle activity transition between fast and slow fiber osteoclast differentiation wound healing regulation of hair cycle skeletal muscle adaptation negative regulation of osteoblast differentiation ventricular septum morphogenesis patterning of lymph vessels heart trabecula morphogenesis cellular response to calcium ion cellular response to tumor necrosis factor cellular response to transforming growth factor beta stimulus mononuclear cell differentiation semi-lunar valve development positive regulation of DNA biosynthetic process negative regulation of stem cell proliferation cellular response to metal ion
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