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Invitrogen
Substance P Polyclonal Antibody
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FIGURE: 1 / 3
Substance P Antibody (PA5-106934) in IHC (P)
Immunohistochemistry analysis of Substance P in mouse testis tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Substance P polyclonal antibody (Product # PA5-106934) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-106934
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TAC1(Accession P20366), corresponding to amino acid residues D38-Y88.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Substance P.
Target Information
Substance P (SP) is currently thought to be one of the most important neurotransmitters and neurotransmitters in the brain. It is an undecapeptide belonging to the tachykinin family, which consists of excitatory neuropeptides synthesised in neuronal and glial cells of the human central and peripheral nervous system. Substance P, Neurokinin A, Neuropeptide K, and Neuropeptide gamma are all generated by post-translation cleavage of the precursor Protachykinin-1. Substance P forms the major endogenous ligand for Neurokinin 1 Receptor. The pharmacology of Substance P has been associated with a number of neurological and psychiatric disorders, namely nociception, migraine, asthma, nausea, inflammatory bowel syndrome, urinary incontinence, anxiety and depression. It has also been linked to obesity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MGC26719; neurokinin 1; neurokinin 2; neurokinin A; neurokinin alpha; neuromedin L; neuropeptide gamma; neuropeptide K; PPT; precursor 1; preprotachykinin; preprotachykinin A; protachykinin; Protachykinin-1; RAT TAC; substance K; substance P; TAC1; Tachykinin (substance P, neurokinin A, neuropeptide K, neuropeptide gamma); tachykinin 1; tachykinin 2; tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
Gene Aliases: 4930528L02Rik; Hs.2563; NK-1; NK1; NK2; NKA; NKNA; NPK; PPT-A; Ppt5fl; PPTA; PPTA3; RATPPTA3; SP; TAC; TAC1; TAC2
UniProt ID: (Human) P20366, (Rat) P06767, (Mouse) P41539
Entrez Gene ID: (Human) 6863, (Rat) 24806, (Mouse) 21333
positive regulation of acute inflammatory response
inflammatory response
positive regulation of cytosolic calcium ion concentration
tachykinin receptor signaling pathway
neuropeptide signaling pathway
chemical synaptic transmission
long-term memory
regulation of blood pressure
associative learning
response to hormone
negative regulation of heart rate
positive regulation of epithelial cell migration
sensory perception of pain
positive regulation of synaptic transmission, cholinergic
positive regulation of synaptic transmission, GABAergic
response to lipopolysaccharide
positive regulation of renal sodium excretion
response to morphine
positive regulation of action potential
positive regulation of ossification
positive regulation of saliva secretion
response to pain
positive regulation of lymphocyte proliferation
positive regulation of stress fiber assembly
positive regulation of corticosterone secretion
cellular response to nerve growth factor stimulus
response to yeast
negative regulation of systemic arterial blood pressure
cell-cell signaling
insemination
detection of abiotic stimulus
antibacterial humoral response
antifungal humoral response
killing of cells of other organism
innate immune response
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
detection of temperature stimulus involved in sensory perception of pain
regulation of sensory perception of pain
antimicrobial humoral immune response mediated by antimicrobial peptide
positive regulation of sperm motility
positive regulation of sensory perception of pain
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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