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Invitrogen
HDAC6 Polyclonal Antibody
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FIGURE: 1 / 2
HDAC6 Antibody (PA5-11240) in IHC (P)
Immunohistochemistry analysis of HDAC6 in paraffin-embedded Human testis tissue. Samples were incubated with HDAC6 polyclonal antibody (Product # PA5-11240) using a dilution of 1:100 for 1 hour at room temperature followed by undiluted CRF Anti-Polyvalent HRP Polymer antibody. Tissue was fixed with formaldehyde at room temperature. Heat induced epitope retrieval was performed by EDTA buffer (pH 9 0).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-11240
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 1182-1215 amino acids from the C-terminal region of human HDAC6
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
200 µg
Purification
Protein A, Affinity chromatography, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-tubulin deacetylase HDAC6; E3 ubiquitin-protein ligase HDAC6; FLJ16239; HDA6; HDAC6; protein phosphatase 1, regulatory subunit 90; tubulin-lysine deacetylase HDAC6; unnamed protein product
Gene Aliases: CPBHM; HD6; JM21; KDAC6; PPP1R90
UniProt ID: (Human) Q9UBN7
Entrez Gene ID: (Human) 10013
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription corepressor binding
histone deacetylase activity
protein binding
beta-catenin binding
microtubule binding
zinc ion binding
deacetylase activity
enzyme binding
polyubiquitin binding
ubiquitin protein ligase binding
protein deacetylase activity
peroxidase inhibitor activity
ATPase inhibitor activity
histone deacetylase binding
tubulin deacetylase activity
alpha-tubulin binding
ubiquitin binding
acetylspermidine deacetylase activity
tau protein binding
beta-tubulin binding
misfolded protein binding
Hsp90 protein binding
ubiquitin protein ligase activity
dynein complex binding
protein deacetylation
misfolded or incompletely synthesized protein catabolic process
intracellular protein transport
response to stress
epidermal growth factor receptor signaling pathway
regulation of autophagy
positive regulation of epithelial cell migration
negative regulation of hydrogen peroxide metabolic process
macroautophagy
regulation of macroautophagy
protein ubiquitination
axonal transport of mitochondrion
negative regulation of protein complex assembly
regulation of protein stability
protein destabilization
lysosome localization
positive regulation of protein oligomerization
regulation of microtubule-based process
positive regulation of intracellular estrogen receptor signaling pathway
cellular response to heat
cellular response to topologically incorrect protein
negative regulation of protein complex disassembly
negative regulation of gene expression, epigenetic
negative regulation of proteolysis
negative regulation of transcription, DNA-templated
negative regulation of cellular component organization
positive regulation of cellular component organization
mitochondrion localization
response to misfolded protein
cilium morphogenesis
regulation of microtubule-based movement
regulation of androgen receptor signaling pathway
cilium disassembly
parkin-mediated mitophagy in response to mitochondrial depolarization
cellular response to hydrogen peroxide
aggresome assembly
polyubiquitinated misfolded protein transport
tubulin deacetylation
macromolecule deacylation
regulation of mitophagy
positive regulation of type 2 mitophagy
negative regulation of aggrephagy
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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