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Invitrogen

Phospho-TLR3 (Tyr858) Polyclonal Antibody

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Phospho-TLR3 (Tyr858) Polyclonal Antibody

Product Details

PA5-114665

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human TLR3 around the phosphorylation site of Tyr858.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2899301

Product Specific Information

Antibody detects endogenous levels of TLR3 only when phosphorylated at Tyr858.

Target Information

TLR3 (Toll-like receptor 3, CD283) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from drosophila to humans and share structural and functional similarities. TLRs recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR3 is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. TLR3 recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. Further, TLR3 may play a role in host defense against viruses, and the use of alternative polyadenylation sites to generate different length transcripts has been noted for the TLR3 gene. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. TLR3 is the only human TLR which does not utilize MyD88 as an adaptor molecule instead utilizing TRIF in a signaling path which results in downstream activation of IRF-3 and NF-kB. TLR3 activation leads not only to Type I interferon induction but also to other inflammatory cytokines which result in DC maturation. TLR3 is known to recognize viral double-stranded (ds) RNA, a molecular pattern associated with viral infection. Recently it has been shown to recognize viruses such as Influenza A and West Nile Virus and can mediate entry of at least West Nile Virus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD283; TLR 3; TLR3; Toll-like receptor 3; unnamed protein product

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Gene Aliases: AI957183; CD283; IIAE2; IMD83; TLR3

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UniProt ID: (Human) O15455, (Mouse) Q99MB1

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Entrez Gene ID: (Human) 7098, (Mouse) 142980

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Function(s)
RNA binding double-stranded RNA binding transmembrane signaling receptor activity protein binding signaling receptor activity pattern recognition receptor activity identical protein binding ubiquitin-like protein ligase binding receptor activity
Process(es)
microglial cell activation positive regulation of cytokine production positive regulation of protein phosphorylation toll-like receptor signaling pathway microglial cell activation involved in immune response immune system process regulation of dendritic cell cytokine production MyD88-independent toll-like receptor signaling pathway defense response inflammatory response signal transduction I-kappaB phosphorylation response to virus positive regulation of type I interferon production positive regulation of chemokine production positive regulation of interferon-beta production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of toll-like receptor signaling pathway toll-like receptor 3 signaling pathway positive regulation of type III interferon production positive regulation of NF-kappaB import into nucleus positive regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA response to dsRNA positive regulation of interferon-gamma biosynthetic process positive regulation of chemokine biosynthetic process innate immune response positive regulation of interferon-alpha biosynthetic process positive regulation of interferon-beta biosynthetic process positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade positive regulation of inflammatory response positive regulation of NF-kappaB transcription factor activity defense response to virus cellular response to exogenous dsRNA extrinsic apoptotic signaling pathway necroptotic signaling pathway MAPK cascade positive regulation of immune system process hyperosmotic response activation of NF-kappaB-inducing kinase activity JNK cascade male gonad development detection of virus positive regulation of gene expression positive regulation of interferon-alpha production positive regulation of interferon-gamma production regulation of toll-like receptor 3 signaling pathway type III interferon production cellular response to interferon-beta defense response to bacterium positive regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of osteoclast differentiation positive regulation of angiogenesis positive regulation of macrophage cytokine production cellular response to mechanical stimulus cellular response to interferon-gamma cellular response to xenobiotic stimulus inflammatory response to wounding cellular response to virus intracellular signaling cassette positive regulation of cytokine production involved in inflammatory response
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