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Invitrogen
AMER1 Polyclonal Antibody
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FIGURE: 1 / 3
AMER1 Antibody (PA5-13492) in IHC (P)
Immunohistochemistry analysis of AMER1 in formalin fixed and paraffin embedded mouse brain tissue. Samples were incubated with AMER1 polyclonal antibody (Product # PA5-13492) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Product Details
PA5-13492
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 681-708 amino acids from the central region of human WTX
Conjugate
Form
Liquid
Concentration
2 mg/mL
Amount
800 µg
Purification
Size-exclusion - Dialysis, Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The AMER1 gene encodes the protein APC membrane recruitment 1, also known as Wilms tumor 1-associating protein (WT1-associating protein). This protein plays a significant role in the Wnt signaling pathway, which is critical for cellular processes such as proliferation, differentiation, and migration. AMER1 interacts with the adenomatous polyposis coli (APC) protein and is involved in the regulation of β-catenin, a key mediator of Wnt signaling. By recruiting APC to the cell membrane, AMER1 facilitates the degradation of β-catenin, thereby acting as a negative regulator of the pathway. This function is vital in maintaining cellular homeostasis and preventing uncontrolled cell growth. Mutations or dysregulation of AMER1 are associated with various cancers, including colorectal cancer, as aberrant Wnt signaling can lead to oncogenesis. Moreover, germline mutations in AMER1 are linked to conditions such as osteoporosis-pseudoglioma syndrome, highlighting its role in bone development and eye health. Ongoing research focuses on elucidating the detailed mechanisms of AMER1's involvement in signaling pathways and its potential as a therapeutic target in cancer and genetic disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adenomatous polyposis coli membrane recruitment 1; Amer1; APC membrane recruitment protein 1; family with sequence similarity 123, member B; family with sequence similarity 123B; Protein FAM123B; RP11-403E24.2; unnamed protein product; Wilms tumor gene on the X chromosome protein; Wilms tumor on the X
Gene Aliases: 2810002O09Rik; AMER1; AW492303; FAM123B; OSCS; WTX
UniProt ID: (Human) Q5JTC6, (Mouse) Q7TS75
Entrez Gene ID: (Human) 139285, (Mouse) 72345
kidney development
Wnt signaling pathway
bone development
adipose tissue development
regulation of canonical Wnt signaling pathway
mesenchymal cell differentiation involved in kidney development
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
positive regulation of protein ubiquitination
positive regulation of protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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