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Invitrogen
TYROBP Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-142466
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-KQRITETESPYQE.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Additional Information: This antibody is expected to recognize both reported isoforms (NP_003323.1; NP_937758.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
DAP12 is a transmembrane adaptor protein that is non-covalently associated with several cell surface receptors on natural killer (NK), myeloid, and presumably neuronal cells. DAP12 contains an ITAM domain that preferentially recruits the protein tyrosine kinase Syk to initiate signal transduction. Deficiency of DAP12 results in reduced antigen presentation function by myeloid cells and defects in function of certain NK cell receptors in mice, as well as presenile dementia and bone cysts in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNAX adaptor protein 12; DNAX-activation protein 12; KAR-associated protein; killer-activating receptor-associated protein; membrane protein; polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy; TYRO protein tyrosine kinase binding protein; TYROBP; unnamed protein product
Gene Aliases: DAP12; KARAP; PLOSL; PLOSL1
UniProt ID: (Human) O43914
Entrez Gene ID: (Human) 7305
negative regulation of cytokine production
stimulatory killer cell immunoglobulin-like receptor signaling pathway
stimulatory C-type lectin receptor signaling pathway
natural killer cell mediated immunity
immune effector process
myeloid leukocyte activation
macrophage activation involved in immune response
microglial cell activation involved in immune response
neutrophil activation involved in immune response
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
positive regulation of immune system process
defense response
immune response
cellular defense response
signal transduction
cell surface receptor signaling pathway
integrin-mediated signaling pathway
positive regulation of gene expression
actin cytoskeleton organization
osteoclast differentiation
negative regulation of B cell proliferation
forebrain development
negative regulation of type I interferon production
negative regulation of interleukin-10 production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
positive regulation of natural killer cell activation
negative regulation of transforming growth factor beta1 production
positive regulation of superoxide anion generation
positive regulation of macrophage fusion
intracellular signal transduction
apoptotic cell clearance
response to axon injury
protein stabilization
semaphorin-plexin signaling pathway
beta-amyloid clearance
negative regulation of long-term synaptic potentiation
positive regulation of receptor localization to synapse
positive regulation of microglial cell mediated cytotoxicity
cellular response to beta-amyloid
positive regulation of protein localization to cell surface
positive regulation of osteoclast development
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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