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Invitrogen
alpha-1 Antitrypsin Polyclonal Antibody
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FIGURE: 1 / 9
alpha-1 Antitrypsin Antibody (PA5-16661) in ICC/IF
Immunofluorescent analysis of Alpha-1-Antitrypsin was performed using 70% confluent log phase Hep G2 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with Alpha-1-Antitrypsin Rabbit Polyclonal Antibody (Product # PA5-16661) at 1:250 dilution in 0.1% BSA and... View More
Product Details
PA5-16661
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Horse,
Human,
Mink,
Non-human primate
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Purified human serum alpha-1-AT
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
purified
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA5-16661 targets Alpha-1-Antitrypsin in IHC (P) applications and shows reactivity with Equine, Human, Mink, monkey, and baboon samples. Does not react with Canine, Chicken, Feline, Guinea Pig, Goat, Marsupial, mouse, Ovine, and Porcine samples
The PA5-16661 immunogen is purified human serum alpha-1-AT.
Target Information
Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: a-1 AT; a1-antitrypsin; alpha 1 antitrypsin; alpha-1 antitrypsin; Alpha-1 protease inhibitor; alpha-1 proteinase inhibitor; Alpha-1-antiproteinase; Alpha-1-antitrypsin; alpha-1-antitrypsin (alpha-1-AT); anti-elastase; Digestive Zymogen; epididymis secretory sperm binding protein; MGC23330; MGC9222; protease inhibitor; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin; Protease Serine 1; proteolytic enzyme inhibitor; serine (or cysteine) proteinase inhibitor, clade A, member 1; Serine Protease 1; Serpin A1; serpin peptidase inhibitor clade A (alpha-1 antiproteinase antitrypsin) member 1 isoform SERPINA1_1; serpin peptidase inhibitor clade A (alpha-1 antiproteinase antitrypsin) member 1 isoform SERPINA1_2; serpin peptidase inhibitor clade A (alpha-1antiproteinase, antitrypsin) member 1; serpin peptidase inhibitor clade A member 1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; TRP1; TRY1; unnamed protein product
Gene Aliases: A1A; A1AT; AAT; alpha1AT; nNIF; PI; PI1; PRO0684; PRO2209; PRO2275; SERPINA1
UniProt ID: (Human) P01009
Entrez Gene ID: (Human) 5265
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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