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Invitrogen
Phospho-HDAC7 (Ser448) Polyclonal Antibody
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FIGURE: 1 / 2
Phospho-HDAC7 (Ser448) Antibody (PA5-23384) in WB
Western blot analysis of Phospho-HDAC7 (Ser448) in recombinant fusion protein. Samples were incubated with Phospho-HDAC7 (Ser448) polyclonal antibody (Product # PA5-23384) using a dilution of 1 µg/mL. (A) recombinant fusion protein containing Ser448 and (B) fusion protein without the phosphorylated amino acid.
Product Details
PA5-23384
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Horse,
Human,
Non-human primate,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Within the range of amino acids 443-460 of human HDAC-7 protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: recombinant fusion protein lysate.
Reacts with Chimpanzee and New World Monkey. Immunogen sequence homology: Mouse (90%).
Target Information
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HD7; HD7a; hdac-7; Histone deacetylase 7; Histone deacetylase 7A; Protein deacetylase HDAC7; unnamed protein product
Gene Aliases: HD7; HD7A; HDAC7; HDAC7A
UniProt ID: (Human) Q8WUI4
Entrez Gene ID: (Human) 51564, (Dog) 486589, (Horse) 100050617, (Bovine) 509843, (Rat) 84582
chromatin binding
transcription corepressor activity
histone deacetylase activity
protein kinase C binding
protein binding
hydrolase activity
SUMO transferase activity
protein kinase binding
protein deacetylase activity
metal ion binding
14-3-3 protein binding
DNA-binding transcription factor binding
histone deacetylase activity, hydrolytic mechanism
molecular_function
transcription factor binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
activating transcription factor binding
NAD-dependent histone deacetylase activity (H3-K9 specific)
NAD-dependent histone deacetylase activity (H4-K16 specific)
repressing transcription factor binding
NAD-dependent histone deacetylase activity (H3-K18 specific)
histone modifying enzyme
negative regulation of transcription from RNA polymerase II promoter
vasculogenesis
chromatin organization
protein deacetylation
cell-cell junction assembly
negative regulation of macromolecule biosynthetic process
protein sumoylation
negative regulation of interleukin-2 production
regulation of gene expression, epigenetic
negative regulation of osteoblast differentiation
negative regulation of transcription, DNA-templated
regulation of mRNA processing
positive regulation of cell migration involved in sprouting angiogenesis
membraneless organelle assembly
negative regulation of NIK/NF-kappaB signaling
transcription, DNA-templated
regulation of transcription, DNA-templated
inflammatory response
nervous system development
chromatin modification
histone deacetylation
neuron differentiation
B cell differentiation
B cell activation
negative regulation of striated muscle tissue development
neuron apoptotic process
histone H3-K9 modification
histone H3 deacetylation
histone H4 deacetylation
cellular response to mechanical stimulus
negative regulation of neuron death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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