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Invitrogen
Claudin 16 Polyclonal Antibody
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FIGURE: 1 / 3
Claudin 16 Antibody (PA5-23939) in IHC (P)
Immunohistochemistry analysis of Claudin 16 in formalin fixed and paraffin embedded human kidney tissue. Samples were incubated with Claudin 16 polyclonal antibody (Product # PA5-23939) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-23939
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 6-33 amino acids from the N-terminal region of human CLDN16
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.4 mg/mL
Amount
160 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Tight junction group of proteins are a cell-to-cell adhesion structure in epithelial cells that constitute the epithelial junctional complex with adherens junctions and desmosomes. Tight junction strands are mainly composed of claudins, occludin, and JAM. Claudin-16 belongs to the Claudin family of protein which is composed of 23 integral membrane proteins. Claudins are responsible for the formation of tight junction strands and are connected with the actin cytoskeleton mediated by ZO-1. Claudin 16, also known as Paracellin-1, is a renal tight junction protein required for paracellular magnesium resorption. It is localized in the intercellular junctions of the epithelial cells of the thick ascending limb of Henle's loop (a TAL marker) are used to localize this specific structure of nephrons in kidney sections. Mg2+ resorption occurs in TAL, and Claudin-16 is required for this paracellular function. Failure in renal 'handling' of magnesium can result in hypermagnesemia, whose major direct toxicity implications are cardiovascular as well as renal failure. Recent studies have shown that the lack of Claudin-16 proteins contributes to the dysfunction of paracellular renal transport systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hypomagnesemia 3, with hypercalciuria and nephrocalcinosis; paracellin-1; PCLN-1; renal tight junction protein
Gene Aliases: HOMG3; PCLN1
UniProt ID: (Human) Q9Y5I7
Entrez Gene ID: (Human) 10686
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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