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Invitrogen
AgRP Polyclonal Antibody
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FIGURE: 1 / 1
AgRP Antibody (PA5-47831) in IHC (F)
Immunohistochemical analysis of AgRP in perfusion fixed frozen sections of mouse brain (hypothalamus). Samples were incubated in AgRP polyclonal antibody (Product # PA5-47831) using a dilution of 1.7 µg/mL overnight at 4 °C followed by NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red) and counterstained with DAPI (blue).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-47831
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Sf 21-derived recombinant mouse AgRP/ART Val25-Thr131
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.2 mg/mL once reconstituted
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, less than 25% cross-reactivity with recombinant human AgRP is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Agouti-related protein (AgRP), also called agouti-related peptide, is a neuropeptide produced in the brain by the AgRP/NPY neuron. In humans, the agouti-related peptide is encoded by the AGRP gene. This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: orexigenic neuropeptide
Gene Aliases: Agrt; Art
UniProt ID: (Mouse) P56473
Entrez Gene ID: (Mouse) 11604
neuropeptide signaling pathway
circadian rhythm
adult feeding behavior
hormone-mediated signaling pathway
regulation of appetite
positive regulation of appetite
response to insulin
eating behavior
long-day photoperiodism
maternal process involved in female pregnancy
regulation of feeding behavior
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
positive regulation of eating behavior
positive regulation of feeding behavior
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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