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Invitrogen
ZAK Polyclonal Antibody
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Product Details
PA5-49885
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from C-terminal of human MLTK.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total ZAK protein.
Target Information
ZAK is a leucine zipper-containing mitogen-activated protein related to the MLKs in both sequence and function. Like the MLKs and other MAP3Ks, ZAK activates MAP2Ks. ZAK is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif. This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HCCS-4; Human cervical cancer suppressor gene 4 protein; Leucine zipper- and sterile alpha motif kinase ZAK; Leucine zipper- and sterile alpha motif-containing kinase; Mitogen-activated protein kinase kinase kinase 20; Mitogen-activated protein kinase kinase kinase MLT; Mixed lineage kinase 7; mixed lineage kinase with a leucine zipper and a sterile alpha motif; Mixed lineage kinase-related kinase; mixed lineage kinase-related kinase MRK-beta; MLK; MLK-like mitogen-activated protein triple kinase; MLK-related kinase; MRK; protein kinase; sterile alpha motif and leucine zipper containing kinase AZK; Sterile alpha motif- and leucine zipper-containing kinase AZK; sterile-alpha motif and leucine zipper containing kinase AZK; unnamed protein product; ZAK1 homolog, leucine zipper and sterile-alpha motif kinase
Gene Aliases: AV006891; AZK; B230120H23Rik; CNM6; HCCS4; MAP3K20; MLK7; mlklak; MLT; MLTK; MLTKalpha; MLTKbeta; MRK; pk; SFMMP; ZAK
UniProt ID: (Human) Q9NYL2, (Mouse) Q9ESL4
Entrez Gene ID: (Human) 51776, (Mouse) 65964
nucleotide binding
magnesium ion binding
RNA binding
protein kinase activity
protein serine/threonine kinase activity
JUN kinase kinase kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
kinase activity
transferase activity
rRNA binding
protein kinase regulator activity
protein kinase activator activity
ribosome binding
metal ion binding
small ribosomal subunit rRNA binding
protein serine kinase activity
stalled ribosome sensor activity
transferase activity, transferring phosphorus-containing groups
poly(A) RNA binding
immunoglobulin
non-receptor serine/threonine protein kinase
DNA damage checkpoint
MAPK cascade
translational initiation
protein phosphorylation
inflammatory response
cytoskeleton organization
chromosome segregation
JNK cascade
cell death
regulation of mitotic metaphase/anaphase transition
cell differentiation
stress-activated protein kinase signaling cascade
intracellular signal transduction
p38MAPK cascade
embryonic digit morphogenesis
positive regulation of apoptotic process
positive regulation of programmed cell death
protein autophosphorylation
stress-activated MAPK cascade
protein maturation
limb development
pyroptosis
negative regulation of stress-activated protein kinase signaling cascade
cellular response to gamma radiation
cellular response to UV-B
GCN2-mediated signaling
negative regulation of translation in response to endoplasmic reticulum stress
positive regulation of mitotic DNA damage checkpoint
NLRP1 inflammasome complex assembly
cell cycle checkpoint
activation of MAPKK activity
cell cycle
cell cycle arrest
activation of JUN kinase activity
response to radiation
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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