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Invitrogen

RAPGEF3 Polyclonal Antibody

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RAPGEF3 Polyclonal Antibody

Product Details

PA5-75508

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to amino acids 799-844 of Human RAPGEF3.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2719236

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Target Information

Gene ontology (GO) annotation includes small GTPase mediated signal transduction. Target protein binds cAMP and activates the Ras superfamily guanine nucleotide binding protein (Rap1A)in a PKA-independent manner.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 9330170P05Rik; cAMP-GEFI; cAMP-regulated guanine nucleotide exchange factor I; cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI); EPAC 1; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; MGC21410; Rap guanine nucleotide exchange factor (GEF) 3; Rap guanine nucleotide exchange factor 3; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; unnamed protein product

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Gene Aliases: 2310016P22Rik; 9330170P05Rik; bcm910; CAMP-GEFI; CGEF1; EPAC; EPAC1; HSU79275; RAPGEF3

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UniProt ID: (Human) O95398, (Rat) Q9Z1C8, (Mouse) Q8VCC8

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Entrez Gene ID: (Human) 10411, (Rat) 59326, (Mouse) 223864

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Function(s)
nucleotide binding guanyl-nucleotide exchange factor activity protein binding protein domain specific binding cAMP binding cAMP-dependent protein kinase regulator activity Rap guanyl-nucleotide exchange factor activity ion channel binding guanyl-nucleotide exchange factor
Process(es)
angiogenesis adaptive immune response signal transduction adenylate cyclase-activating G-protein coupled receptor signaling pathway small GTPase mediated signal transduction Ras protein signal transduction associative learning Rap protein signal transduction regulation of actin cytoskeleton organization negative regulation of syncytium formation by plasma membrane fusion intracellular signal transduction protein kinase B signaling positive regulation of GTPase activity regulation of angiogenesis positive regulation of angiogenesis positive regulation of protein export from nucleus regulation of insulin secretion positive regulation of stress fiber assembly regulation of protein kinase B signaling positive regulation of syncytium formation by plasma membrane fusion establishment of endothelial barrier cellular response to cAMP positive regulation of peptidyl-serine phosphorylation regulation of protein kinase activity positive regulation of protein acetylation regulation of actin cytoskeleton reorganization regulation of histone H3-K9 acetylation regulation of protein phosphorylation positive regulation of protein phosphorylation positive regulation of smooth muscle cell migration positive regulation of ATPase activity negative regulation of collagen biosynthetic process positive regulation of cell size positive regulation of transcription from RNA polymerase II promoter positive regulation of binding positive regulation of calcium ion transport negative regulation of cell death positive regulation of actin cytoskeleton reorganization
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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