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Invitrogen
GABRA6 Polyclonal Antibody
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FIGURE: 1 / 3
GABRA6 Antibody (PA5-78387) in WB
Western Blot using GABRA6 Polyclonal Antibody (Product # PA5-78387). Human tissue extract (30 µg) was separated by 10% SDS-PAGE, and the membrane was blotted with GABRA6 Polyclonal Antibody (Product # PA5-78387) diluted at 1:5,000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
Product Details
PA5-78387
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide encompassing a sequence within the Intracellular domain of human GABA A Receptor alpha 6. The exact sequence is proprietary.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.98 mg/mL
Amount
198 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: Mouse brain, rat brain
Predicted Reactivity: Human (100%), Bovine (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABA-A Receptor (GABA-A R) Subtype. GABA-A Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha and beta subunits results in the expression of functional GABA-A Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha subunits of the receptor. Lastly, phosphorylation of beta subunits of the receptor has been shown to modulate GABA-A R function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GABA subunit A receptor alpha 6; GABA(A) receptor subunit alpha-6; GABA(A) receptor, alpha 6; GABA-A receptor alpha-6 subunit; GABAAR alpha6; GABAAR subunit alpha-6; GABRA 6; gamma-aminobutyric acid; gamma-aminobutyric acid A receptor, alpha 6; gamma-aminobutyric acid (GABA) A receptor, alpha 6; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6; gamma-aminobutyric acid A receptor, alpha 6; Gamma-aminobutyric acid receptor subunit alpha-6; gamma-aminobutyric acid type A receptor alpha6 subunit; subunit alpha 6 gamma-aminobutyric acid (GABA-A) receptor; unnamed protein product
Gene Aliases: alpha6; GABA-ARalpha6; Gabra-6; GABRA6
UniProt ID: (Human) Q16445, (Mouse) P16305, (Rat) P30191
Entrez Gene ID: (Human) 2559, (Mouse) 14399, (Rat) 29708
transmembrane signaling receptor activity
GABA-A receptor activity
ion channel activity
extracellular ligand-gated ion channel activity
chloride channel activity
benzodiazepine receptor activity
GABA-gated chloride ion channel activity
signaling receptor activity
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
inhibitory extracellular ligand-gated ion channel activity
drug binding
ligand-gated ion channel
ion transport
chloride transport
signal transduction
gamma-aminobutyric acid signaling pathway
ion transmembrane transport
synaptic transmission, GABAergic
regulation of postsynaptic membrane potential
chloride transmembrane transport
inhibitory synapse assembly
transport
protein heterooligomerization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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