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Invitrogen

beta Arrestin 1 Polyclonal Antibody

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beta Arrestin 1 Polyclonal Antibody

Product Details

PA5-78823

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human beta Arrestin 1 (82-103aa ANVQSFPPAPEDKKPLTRLQER).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide, 0.05mg thimerosal

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2745939

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: Rat Lung Tissue, Rat Skeletal Muscle Tissue, SW620 Cell. IHC: Human Mammary Cancer Tissue.

Target Information

Beta Arrestin 1 is a member of a family of proteins widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of Gprotein-coupled receptors (GPCRs, e.g., beta 2-adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: arrestin; Arrestin beta-1; beta-arrestin; Beta-arrestin-1; beta-arrestin1; Non-visual arrestin-2

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Gene Aliases: 1200006I17Rik; ARR1; ARRB1; AW208571; BARRES; G430100A01Rik

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UniProt ID: (Rat) P29066, (Mouse) Q8BWG8

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Entrez Gene ID: (Rat) 25387, (Mouse) 109689

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Function(s)
G-protein coupled receptor binding histone acetyltransferase activity GTPase activator activity insulin-like growth factor receptor binding protein binding transcription factor binding clathrin binding estrogen receptor binding mitogen-activated protein kinase kinase binding ubiquitin protein ligase binding alpha-1A adrenergic receptor binding alpha-1B adrenergic receptor binding angiotensin receptor binding follicle-stimulating hormone receptor binding V2 vasopressin receptor binding AP-2 adaptor complex binding clathrin adaptor activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process transcription regulatory region DNA binding ion channel binding protein phosphorylated amino acid binding phosphoprotein binding scaffold/adaptor protein
Process(es)
activation of MAPK activity negative regulation of protein phosphorylation positive regulation of protein phosphorylation G-protein coupled receptor internalization desensitization of G-protein coupled receptor protein signaling pathway by arrestin positive regulation of receptor internalization transcription from RNA polymerase II promoter endocytosis receptor-mediated endocytosis G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway phototransduction regulation of G-protein coupled receptor protein signaling pathway protein transport protein ubiquitination sensory perception of pain regulation of cAMP biosynthetic process regulation of cAMP catabolic process negative regulation of protein ubiquitination positive regulation of protein ubiquitination negative regulation of NF-kappaB transcription factor activity positive regulation of protein binding negative regulation of interleukin-6 production negative regulation of interleukin-8 production positive regulation of peptidyl-serine phosphorylation negative regulation of GTPase activity positive regulation of smooth muscle cell apoptotic process positive regulation of Rho protein signal transduction positive regulation of histone acetylation positive regulation of insulin secretion involved in cellular response to glucose stimulus follicle-stimulating hormone signaling pathway stress fiber assembly negative regulation of cysteine-type endopeptidase activity involved in apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of GTPase activity positive regulation of transcription from RNA polymerase II promoter sensory perception of touch negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of histone H4 acetylation transcription, DNA-templated regulation of transcription, DNA-templated transport signal transduction negative regulation of signal transduction
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