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Invitrogen
K-Ras Polyclonal Antibody
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FIGURE: 1 / 1
K-Ras Antibody (PA5-81515) in WB
Western Blot using K-Ras Polyclonal Antibody (Product # PA5-81515) at 1:500 dilution. Lane A: Mouse lung tissue lysate. Lysates/proteins at 30 μg per lane. Secondary Goat Anti- RabbitIgG H&L (DyLight™ 800) at 1:10,000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 22 kDa. Observed band size: 22 kDa. (We are unsure of the identity of these extra bands).
Product Details
PA5-81515
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to the center region of the Human K-Ras
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.0
Contains
0.03% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human KRAS.
Target Information
K-RAS (GTPase KRas) belongs to the Ras oncogene family. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. It plays an important role in the regulation of cell proliferation and has a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes in colorectal cancer cells in a ZNF304-dependent manner. Mutations in the gene can result in leukemia acute myelogenous, leukemia juvenile myelomonocytic, Noonan Syndrome, gastric cancer, and cardiofaciocutaneous syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-K-ras; c-Ki-ras; c-Kirsten-ras protein; c-ras-Ki-2 protein; cellular c-Ki-ras2; cellular c-Ki-ras2 proto-oncogene; cellular transforming proto-oncogene; GTPase KRas; K RAS; K-Ras 2; K-ras p21 protein; Ki-Ras; Kirsten rat sarcoma viral oncogene homolog; Kirsten rat sarcoma viral proto-oncogene; KRAS-ENOPH fusion; Kras-Enoph1 fusion protein; oncogene KRAS2; PR310 c-K-ras oncogene; PR371 c-K-ras oncogene; proto-oncogene GTPase; RASK; small GTP binding protein; transforming protein p21; unnamed protein product; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog
Gene Aliases: 'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2; CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; KRAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2
UniProt ID: (Human) P01116
Entrez Gene ID: (Human) 3845
MAPK cascade
liver development
signal transduction
Ras protein signal transduction
female pregnancy
cell proliferation
visual learning
response to gravity
gene expression
positive regulation of gene expression
glial cell proliferation
Rac protein signal transduction
cytokine-mediated signaling pathway
forebrain astrocyte development
actin cytoskeleton organization
negative regulation of epithelial cell differentiation
regulation of synaptic transmission, GABAergic
positive regulation of Rac protein signal transduction
response to isolation stress
skeletal muscle cell differentiation
negative regulation of neuron apoptotic process
regulation of long-term neuronal synaptic plasticity
homeostasis of number of cells within a tissue
striated muscle cell differentiation
response to glucocorticoid
response to mineralocorticoid
neuron apoptotic process
myoblast proliferation
cardiac muscle cell proliferation
positive regulation of glial cell proliferation
epithelial tube branching involved in lung morphogenesis
Type I pneumocyte differentiation
positive regulation of cellular senescence
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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