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Invitrogen

PBX1 Polyclonal Antibody

View all (24) PBX1 antibodies

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PBX1 Polyclonal Antibody

Product Details

PA5-82118

Applications
Tested Dilution
Publications

Western Blot (WB)

0.04-0.4 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL
-

ChIP assay (ChIP)

1-10 µg
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PBX1. Recombinant protein control fragment (Product #RP-101911).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Amount

10 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2789279

Product Specific Information

Immunogen sequence: YSHLSNPYPS EEAKEELAKK CGITVSQVSN WFGNKRIRYK KNIGKFQEEA NIYAAKTAVT ATNVSAHGSQ ANSPSTPNSA GSSSSFNMSN SGDLFMSVQS LNGDSYQGAQ VGANVQSQVD TLRHVISQTG GYSDGLAASQ MYSP

Highest antigen sequence indentity to the following orthologs: Rat - 100%, Mouse - 100%.

Target Information

This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1; 19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZp686B09108; Homeobox protein PBX1; Homeobox protein PRL; homeobox-containing protein; MGC126627; OTTHUMP00000032205; pre-B-cell leukemia homeobox 1; Pre-B-cell leukemia transcription factor 1; unnamed protein product

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Gene Aliases: CAKUHED; PBX1; PRL

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UniProt ID: (Human) P40424

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Entrez Gene ID: (Human) 5087

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription cofactor binding transcription corepressor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding sequence-specific DNA binding DNA-binding transcription factor binding sequence-specific double-stranded DNA binding
Process(es)
G2/M transition of mitotic cell cycle eye development urogenital system development branching involved in ureteric bud morphogenesis natural killer cell differentiation regulation of transcription, DNA-templated steroid biosynthetic process brain development sex differentiation cell proliferation organ morphogenesis anterior/posterior pattern specification proximal/distal pattern formation positive regulation of G2/M transition of mitotic cell cycle cell differentiation regulation of ossification adrenal gland development embryonic limb morphogenesis embryonic hemopoiesis regulation of cell proliferation negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of neuron differentiation positive regulation of transcription from RNA polymerase II promoter spleen development thymus development embryonic organ development neuron development embryonic skeletal system development stem cell proliferation positive regulation of stem cell proliferation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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