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Invitrogen
RBL1 Polyclonal Antibody
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Product Details
PA5-84228
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RBL1. Recombinant protein control fragment (Product #RP-95260).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ESLAWSHDSA LWEALQVSAN KVPTCEEVIF PNNFETGNGG NVQGHLPLMP MSPLMHPRVK EVRTDSGSLR RDMQPLSPIS VHER
Highest antigen sequence indentity to the following orthologs: Mouse - 86%, Rat - 86%.
Target Information
RB-like 1 is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and RB-like 1 can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that RB-like 1 may also be a tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 107 kDa retinoblastoma-associated protein; MGC40006; p107; pRb1; retinoblastoma-like 1; Retinoblastoma-like protein 1; unnamed protein product
Gene Aliases: CP107; p107; PRB1; RBL1
UniProt ID: (Human) P28749
Entrez Gene ID: (Human) 5933
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
regulation of transcription from RNA polymerase II promoter
regulation of gene expression
negative regulation of macromolecule biosynthetic process
negative regulation of gene expression
cell differentiation
regulation of lipid kinase activity
regulation of cell cycle
negative regulation of G1/S transition of mitotic cell cycle
negative regulation of cellular senescence
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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