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Invitrogen

CD32 Polyclonal Antibody

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CD32 Polyclonal Antibody

Product Details

PA5-87604

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:4,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein (or fragment)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.49 mg/mL

Amount

149 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2804283

Product Specific Information

Immunogen sequence: TPAAPPKAVL KLEPQWINVL QEDSVTLTCR GTHSPESDSI PWFHNGNLIP THTQPSYRFK ANNNDSGEYT CQTGQTSLSD PVHLTVLSEW LVLQTPHLEF QEGETIVLRC HSWKDKPLVK VTFFQNGKSK KFSRSDPNFS IPQANHSHSG DYHCTGNIGY TLYSSKPVTI TVQAPSSSPM G; Positive Samples: THP-1, 22Rv1; Cellular Location: Cell membrane, Cytoplasm, Single-pass type I membrane protein

Target Information

This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD32 receptor 2; CD32 receptor 2a; CDw32; Fc fragment of IgG receptor IIa; Fc fragment of IgG receptor IIb; Fc fragment of IgG receptor IIc; Fc fragment of IgG, low affinity II, receptor for (CD32); Fc fragment of IgG, low affinity IIa, receptor (CD32); Fc fragment of IgG, low affinity IIb, receptor (CD32); Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity IIc, receptor for (CD32); Fc gamma receptor IIC; Fc gamma receptor RIIa3; Fc gamma RIIb; fc-gamma RII-b; fc-gamma-RIIa; fc-gamma-RIIb; fc-gamma-RIIc; fc?r; FCGR2B; FcgRIIa3 splice variant; fcRII-a; fcRII-b; FGFR2B; IgG Fc fragment receptor; IgG Fc fragment receptor precursor; IgG Fc receptor alpha-Fc-gamma-RII; IgG Fc receptor beta-Fc-gamma-RII; igG Fc receptor II-a; igG Fc receptor II-b; IgG Fc receptor II-c; IgG Fc receptor precursor; Immunoglobulin G Fc receptor II; immunoglobulin G Fc receptor II-c; MGC23887; MGC30032; RP11-5K23.6; unnamed protein product

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Gene Aliases: CD32; CD32A; CD32B; CD32C; CDW32; FCG2; FcgammaRIIa; FcgammaRIIc; FcGR; FCGR2; FCGR2A1; FCRIIC; IGFR2

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UniProt ID: (Human) P12318, (Human) P31994, (Human) P31995

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Entrez Gene ID: (Human) 2212, (Human) 2213, (Human) 9103

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Function(s)
protein binding IgG receptor activity IgG binding beta-amyloid binding low-affinity IgG receptor activity macromolecular complex binding transmembrane signaling receptor activity
Process(es)
antibody-dependent cellular cytotoxicity regulation of immune system process immune response cell surface receptor signaling pathway positive regulation of tumor necrosis factor production Fc-gamma receptor signaling pathway positive regulation of phagocytosis negative regulation of type I hypersensitivity negative regulation of antibody-dependent cellular cytotoxicity negative regulation of cytokine production immune effector process follicular dendritic cell activation mature B cell differentiation involved in immune response follicular B cell differentiation immune complex clearance by monocytes and macrophages negative regulation of dendritic cell antigen processing and presentation regulation of B cell antigen processing and presentation negative regulation of immunoglobulin production regulation of adaptive immune response negative regulation of acute inflammatory response to antigenic stimulus positive regulation of humoral immune response negative regulation of humoral immune response mediated by circulating immunoglobulin receptor-mediated endocytosis phagocytosis defense response inflammatory response response to bacterium immunoglobulin mediated immune response antigen processing and presentation of exogenous peptide antigen via MHC class II negative regulation of B cell proliferation negative regulation of interleukin-10 production negative regulation of macrophage activation negative regulation of cytotoxic T cell degranulation regulation of innate immune response positive regulation of JNK cascade negative regulation of phagocytosis negative regulation of immune response negative regulation of B cell receptor signaling pathway negative regulation of B cell activation regulation of immune complex clearance by monocytes and macrophages negative regulation of neutrophil activation regulation of dendritic spine maintenance regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway cellular response to beta-amyloid positive regulation of response to endoplasmic reticulum stress negative regulation of dendritic cell differentiation
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